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Primary intestinal lymphangiectasia diagnosed by capsule endoscopy and double balloon enteros

 Tak Geun Oh  ;  Joo Won Chung  ;  Si Young Song  ;  Jung Yeob Park  ;  Jin Sung Lee  ;  Seok-Joo Han  ;  Hee Man Kim 
 World Journal of Gastrointestinal Endoscopy, Vol.3(11) : 235-240, 2011 
Journal Title
 World Journal of Gastrointestinal Endoscopy 
Issue Date
Primary intestinal lymphangiectasia (PIL) is a rare disorder characterized by dilated intestinal lymphatics and the development of protein-losing enteropathy. Patients with PIL develop hypoalbuminemia, hypocalcemia, lymphopenia and hypogammaglobulinemia, and present with bilateral lower limb edema, fatigue, abdominal pain and diarrhea. Endoscopy reveals diffusely elongated, circumferential and polypoid mucosae covered with whitish enlarged villi, all of which indicate intestinal lymphangiectasia. Diagnosis is confirmed by characteristic tissue pathology, which includes dilated intestinal lymphatics with diffusely swollen mucosa and enlarged villi. The prevalence of PIL has increased since the introduction of capsule endoscopy. The etiology and prevalence of PIL remain unknown. Some studies have reported that several genes and regulatory molecules for lymphangiogenesis are related to PIL. We report the case of a patient with PIL involving the entire small bowel that was confirmed by capsule endoscopy and double-balloon enteroscopy-guided tissue pathology who carried a deletion on chromosome 4q25. The relationship between this deletion on chromosome 4 and PIL remains to be investigated.
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김희만(Kim, Hee Man) ; 박정엽(Park, Jeong Youp) ; 송시영(Song, Si Young) ; 오탁근(Oh, Tak Geun) ; 정주원(Chung, Joo Won) ; 한석주(Han, Seok Joo)
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