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Failure of a Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy of H. pylori Eradication in H. pylori-Infected Patients with Functional Dyspepsia

 Su Jin Hong  ;  In Kyung Sung  ;  The H. pylori and Dyspepsia Study Group of Korean College of Helicobacter and Upper Gastrointestinal Research  ;  Sang Young Seol  ;  Byung Joo Park  ;  Sue K. Park  ;  Moo In Park  ;  Seong Woo Jeon  ;  Gwang Ha Kim  ;  Dong Ho Lee  ;  Sang In Lee  ;  Chang Hun Yang  ;  Suck Chei Choi  ;  Sang Woo Lee  ;  Jae Gyu Kim 
 Gut and Liver, Vol.5(4) : 468-471, 2011 
Journal Title
 Gut and Liver 
Issue Date
BACKGROUND/AIMS: The role of Helicobacter pylori eradication in patients with functional dyspepsia (FD) is still uncertain. We originally planned a randomized clinical study to observe dyspeptic symptoms after H. pylori eradication therapy. However, we failed to complete the study; therefore, we analyzed the factors that affected the failure of the study. METHODS: Interviews and questionnaire surveys were conducted to analyze the factors that induced early termination from the study. RESULTS: Many patients were screened by gastroenterologists at 11 tertiary referral hospitals between July 2009 and August 2010; however, only 4 patients met the enrollment criteria. Most patients who visited our clinics had been experiencing FD symptoms for less than 6 months or were already taking medication. They also demanded to continue taking medications and using other drugs. Only 3 of the 4 patients signed informed consent. CONCLUSIONS: The application of the current Rome III criteria to FD is difficult to evaluate in Korean patients with dyspeptic symptoms because of the early medical evaluation. Most Korean patients who were diagnosed with FD by the Rome III criteria did not overcome their fear of being unable to use rescue medications during the study period.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
이상인(Lee, Sang In)
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