5 92

Cited 11 times in

Asynchronous arterial systolic expansion as a marker of vascular aging: assessment of the carotid artery with velocity vector imaging

 Yang, Woo-In  ;  Shim, Chi Y.  ;  Ha, Jong-Won  ;  Chung, Namsik  ;  Chang, Hyuk J.  ;  Oh, Chang M.  ;  Bang, Woo D. 
 Journal of Hypertension, Vol.29(12) : 2404-2412, 2011 
Journal Title
 Journal of Hypertension 
Issue Date
OBJECTIVE: Arterial elastic properties change with aging. Measurements of pulse wave velocity and augmentation index are useful for the evaluation of arterial stiffness. However, they likely represent only global characteristics of the arterial tree rather than local vascular alterations. The aim of this study was to evaluate whether local vascular properties assessed by velocity vector imaging differed with aging. METHODS: Vascular properties of carotid arteries with ages were assessed in 100 healthy volunteers (52 men) ranging from 20 to 68 years using velocity vector imaging. The peak circumferential strain and strain rate of the six segments in left common carotid arteries were analyzed and the standard deviation of the time to peak circumferential strain and strain rate of the six segments, representing the synchronicity of the arterial expansion, were calculated. Central blood pressure, augmentation index and pulse wave velocity were assessed by commercially available radial artery tonometry, the SphygmoCor system (AtCor Medical, West Ryde, Australia). A validated generalized transfer function was used to acquire the central aortic pressures and pressure waveforms. RESULTS: Pulse wave velocity, augmentation index and velocity vector imaging parameters showed significant changes with age. However, the age-related changes in pulse wave velocity, augmentation index and velocity vector imaging parameters were different. The increase in pulse wave velocity was more prominent in older individuals, whereas the changes in augmentation index and carotid strain and strain rate were evident earlier, at the age of 30 years. Unlike augmentation index, which showed little change in older individuals, the standard deviation of time to peak strain and strain rate showed a steady increase from younger to older individuals. CONCLUSION: Asynchronous arterial expansion could be a useful discriminative marker of vascular aging independent of individual's age.
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
방우대(Bang, Woo Dae) ; 심지영(Shim, Chi Young) ; 양우인(Yang, Woo In) ; 오창명(Oh, Chang Myung) ; 장혁재(Chang, Hyuck Jae) ; 정남식(Chung, Nam Sik) ; 하종원(Ha, Jong Won)
사서에게 알리기
Full Text
RIS (EndNote)
XLS (Excel)


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.