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Acute kidney injury in critically ill patients with pandemic influenza A pneumonia 2009 in Korea: a multicenter study.

 Ji Ye Jung  ;  Byung Hoon Park  ;  Sang-Bum Hong  ;  Younsuck Koh  ;  Gee Young Suh  ;  Kyeongman Jeon  ;  Shin Ok Koh  ;  Jae Yeol Kim  ;  Jae Hwa Cho  ;  Hye Sook Choi  ;  Yong Bum Park  ;  Ho Cheol Kim  ;  Yeon-Sook Kim  ;  Chang Young Lim  ;  Moo Suk Park 
 Journal of Critical Care, Vol.26(6) : 577-585, 2011 
Journal Title
 Journal of Critical Care 
Issue Date
APACHE ; Acute Kidney Injury/complications* ; Aged ; Critical Care ; Female ; Hospitalization ; Humans ; Influenza A Virus, H1N1 Subtype* ; Influenza, Human/complications ; Influenza, Human/epidemiology* ; Intensive Care Units ; Male ; Middle Aged ; Pneumonia, Viral/complications ; Pneumonia, Viral/epidemiology* ; Republic of Korea/epidemiology ; Retrospective Studies ; Risk Factors
Acute kidney injury ; Influenza A ; Pneumonia ; Critical care
OBJECTIVES: We assessed the incidence and clinical characteristics of acute kidney injury (AKI) in critically ill patients infected with pandemic influenza A (H1N1) and its effect on clinical outcomes. METHODS: We conducted a multicenter, retrospective, observational study of patients with pandemic H1N1-related critical illness admitted to intensive care units (ICUs) of 28 tertiary or referral hospitals in South Korea between September 1, 2009, and February 28, 2010. Outcomes were AKI within 72 hours after ICU admission and 30-day mortality. Acute kidney injury was defined according to the Risk, Injury, Failure, Loss, and End-stage renal failure criteria. RESULTS: Of the 221 patients, 50 (22.6%) developed AKI within 72 hours after ICU admission. Independent risk factors for AKI were age (odds ratio [OR], 1.05; P = .003), chronic kidney disease (OR, 14.82; P = .004), and Sequential Organ Failure Assessment score (OR, 1.45; P < .001). Age (OR, 1.04; P = .003), Sequential Organ Failure Assessment score (OR, 1.28; P = .012), state of immune suppression (OR, 4.09; P = .01), mechanical ventilation (OR, 18.24; P = .001), corticosteroid use (OR, 3.09; P = .007), and AKI (OR, 2.86; P = .035) were significantly associated with 30-day mortality. CONCLUSIONS: A significant number of patients with H1N1-related critical illness developed AKI within 72 hours of ICU admission, and this early development of AKI was associated with 30-day mortality.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Koh, Shin Ok(고신옥)
Park, Moo Suk(박무석) ORCID logo https://orcid.org/0000-0003-0820-7615
Park, Byung Hoon(박병훈)
Jung, Ji Ye(정지예) ORCID logo https://orcid.org/0000-0003-1589-4142
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