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근관 삼출액에서의 기질금속단백분해효소-8과 substance P의 수준에 관한 연구
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 신수정 | - |
dc.date.accessioned | 2014-12-20T17:24:29Z | - |
dc.date.available | 2014-12-20T17:24:29Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1225-0864 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/94545 | - |
dc.description.abstract | OBJECTIVES: The aim of this study was to investigate levels of matrix metalloproteinase-8 (MMP-8) and substance P (SP) in root canal exudates during root canal treatment (RCT) of nonvital, painful teeth. MATERIALS AND METHODS: Patients scheduled for nonsurgical RCT were prospectively selected; the study was performed after obtaining informed consent from the patients and was approved by the Institutional Review Board for Clinical Research of Gangnam Severance Hospital, Yonsei University (3-2008-0118). Canal exudates samples were collected using sterilized paper points from teeth scheduled for RCT across three different time periods. MMP-8 and SP levels were measured using enzyme-linked immunosorbent assay (ELISA). Data were analyzed using a mixed model analysis and the Pearson correlation analysis (p < 0.05). RESULTS: MMP-8 and SP levels in GCF were decreased during RCT (p < 0.0001), and they showed a weak positive correlation to each other (p < 0.05). Patients'subjective pain levels and the response from percussion test were significantly related to SP level. CONCLUSIONS: This study demonstrated that periradicular inflammation endodontic origin can elevate SP and MMP-8 levels in root canal exudates. Interestingly, SP level of canal exudates showed a possibility of being used as an indicator of pain due to periapical pathosis | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 196~202 | - |
dc.relation.isPartOf | Journal of Korean Academy of Operative Dentistry (대한치과보존학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Gingival Crevicular Fluid/chemistry* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Inflammation Mediators/analysis | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Matrix Metalloproteinase 8/analysis* | - |
dc.subject.MESH | Neurotransmitter Agents/analysis* | - |
dc.subject.MESH | Pain Measurement | - |
dc.subject.MESH | Periapical Periodontitis/metabolism | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Root Canal Irrigants/therapeutic use | - |
dc.subject.MESH | Root Canal Obturation/methods | - |
dc.subject.MESH | Root Canal Preparation/instrumentation | - |
dc.subject.MESH | Root Canal Therapy* | - |
dc.subject.MESH | Sodium Hypochlorite/therapeutic use | - |
dc.subject.MESH | Substance P/analysis* | - |
dc.subject.MESH | Tooth, Nonvital/metabolism | - |
dc.subject.MESH | Tooth, Nonvital/therapy* | - |
dc.subject.MESH | Toothache/metabolism | - |
dc.title | 근관 삼출액에서의 기질금속단백분해효소-8과 substance P의 수준에 관한 연구 | - |
dc.title.alternative | Matrix metalloproteinase-8 and substance P levels in root canal exudates of nonvital teeth | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Conservative Dentistry (보존과학) | - |
dc.contributor.googleauthor | 신수정 | - |
dc.contributor.googleauthor | 이우철 | - |
dc.contributor.googleauthor | 이재일 | - |
dc.contributor.googleauthor | 백승호 | - |
dc.contributor.googleauthor | 금기연 | - |
dc.contributor.googleauthor | 손원준 | - |
dc.contributor.googleauthor | 배광식 | - |
dc.identifier.doi | 10.5395/JKACD.2011.36.3.196 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02117 | - |
dc.relation.journalcode | J01488 | - |
dc.identifier.pmid | 21831678 | - |
dc.contributor.alternativeName | Shin, Su Jung | - |
dc.contributor.affiliatedAuthor | Shin, Su Jung | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 36 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 196 | - |
dc.citation.endPage | 202 | - |
dc.identifier.bibliographicCitation | Journal of Korean Academy of Operative Dentistry (대한치과보존학회지), Vol.36(3) : 196-202, 2011 | - |
dc.identifier.rimsid | 27404 | - |
dc.type.rims | ART | - |
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