320 679

Cited 24 times in

Non-dipper status and left ventricular hypertrophy as predictors of incident chronic kidney disease

Authors
 Hye Rim An  ;  Sungha Park  ;  Tae-Hyun Yoo  ;  Shin-Wook Kang  ;  Jung-Hwa Ryu  ;  Yong Kyu Lee  ;  Mina Yu  ;  Dong-Ryeol Ryu  ;  Seung Jung Kim  ;  Duk-Hee Kang  ;  Kyu Bok Choi 
Citation
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.26(9) : 1185-1190, 2011 
Journal Title
JOURNAL OF KOREAN MEDICAL SCIENCE
ISSN
 1011-8934 
Issue Date
2011
MeSH
Adult ; Aged ; Aged, 80 and over ; Albumins/analysis ; Blood Pressure ; Blood Pressure Monitoring, Ambulatory ; Cholesterol, HDL/blood ; Chronic Disease ; Creatinine/blood ; Creatinine/urine ; Cross-Sectional Studies ; Female ; Follow-Up Studies ; Glomerular Filtration Rate ; Humans ; Hypertension/complications ; Hypertrophy, Left Ventricular/complications ; Hypertrophy, Left Ventricular/diagnosis* ; Incidence ; Kidney Diseases/diagnostic imaging ; Kidney Diseases/epidemiology ; Kidney Diseases/etiology* ; Male ; Middle Aged ; Predictive Value of Tests* ; Retrospective Studies ; Ultrasonography
Keywords
Blood Pressure Monitoring ; Ambulatory ; Hypertrophy ; Left Ventricular ; Renal Insufficiency ; Chronic
Abstract
We have hypothesized that non-dipper status and left ventricular hypertrophy (LVH) are associated with the development of chronic kidney disease (CKD) in non-diabetic hypertensive patients. This study included 102 patients with an estimated glomerular filtration rate (eGFR) ≥ 60 mL/min/1.73 m(2). Ambulatory blood pressure monitoring and echocardiography were performed at the beginning of the study, and the serum creatinine levels were followed. During the average follow-up period of 51 months, CKD developed in 11 patients. There was a significant difference in the incidence of CKD between dippers and non-dippers (5.0% vs 19.0%, P < 0.05). Compared to patients without CKD, patients with incident CKD had a higher urine albumin/creatinine ratio (52.3 ± 58.6 mg/g vs 17.8 ± 29.3 mg/g, P < 0.01), non-dipper status (72.7% vs 37.4%, P < 0.05), the presence of LVH (27.3% vs 5.5%, P < 0.05), and a lower serum HDL-cholesterol level (41.7 ± 8.3 mg/dL vs 50.4 ± 12.4 mg/dL, P < 0.05). Based on multivariate Cox regression analysis, non-dipper status and the presence of LVH were independent predictors of incident CKD. These findings suggest that non-dipper status and LVH may be the therapeutic targets for preventing the development of CKD in non-diabetic hypertensive patients.
Files in This Item:
T201103894.pdf Download
DOI
10.3346/jkms.2011.26.9.1185
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Shin Wook(강신욱) ORCID logo https://orcid.org/0000-0002-5677-4756
Park, Sung Ha(박성하) ORCID logo https://orcid.org/0000-0001-5362-478X
Yoo, Tae Hyun(유태현) ORCID logo https://orcid.org/0000-0002-9183-4507
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94530
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links