Cited 710 times in
Drosophila microbiome modulates host developmental and metabolic homeostasis via insulin signaling
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 유지환 | - |
dc.contributor.author | 윤주헌 | - |
dc.date.accessioned | 2014-12-20T17:21:28Z | - |
dc.date.available | 2014-12-20T17:21:28Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0036-8075 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/94449 | - |
dc.description.abstract | The symbiotic microbiota profoundly affect many aspects of host physiology; however, the molecular mechanisms underlying host-microbe cross-talk are largely unknown. Here, we show that the pyrroloquinoline quinone-dependent alcohol dehydrogenase (PQQ-ADH) activity of a commensal bacterium, Acetobacter pomorum, modulates insulin/insulin-like growth factor signaling (IIS) in Drosophila to regulate host homeostatic programs controlling developmental rate, body size, energy metabolism, and intestinal stem cell activity. Germ-free animals monoassociated with PQQ-ADH mutant bacteria displayed severe deregulation of developmental and metabolic homeostasis. Importantly, these defects were reversed by enhancing host IIS or by supplementing the diet with acetic acid, the metabolic product of PQQ-ADH | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 670~674 | - |
dc.relation.isPartOf | SCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Acetobacter/genetics | - |
dc.subject.MESH | Acetobacter/physiology* | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Body Size/genetics | - |
dc.subject.MESH | Carbohydrate Dehydrogenases/metabolism* | - |
dc.subject.MESH | Drosophila/growth & development | - |
dc.subject.MESH | Drosophila/microbiology* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Homeostasis | - |
dc.subject.MESH | Insulin/metabolism* | - |
dc.subject.MESH | Intestines/microbiology | - |
dc.subject.MESH | Metagenome/physiology* | - |
dc.subject.MESH | Signal Transduction* | - |
dc.subject.MESH | Somatomedins/metabolism | - |
dc.title | Drosophila microbiome modulates host developmental and metabolic homeostasis via insulin signaling | - |
dc.type | Article | - |
dc.contributor.college | Researcher Institutes (부설 연구소) | - |
dc.contributor.department | 생체방어연구센터 | - |
dc.contributor.googleauthor | Seung Chul Shin | - |
dc.contributor.googleauthor | Sung-Hee Kim | - |
dc.contributor.googleauthor | Hyejin You | - |
dc.contributor.googleauthor | Boram Kim | - |
dc.contributor.googleauthor | Aeri C. Kim | - |
dc.contributor.googleauthor | Kyung-Ah Lee | - |
dc.contributor.googleauthor | Joo-Heon Yoon | - |
dc.contributor.googleauthor | Ji-Hwan Ryu | - |
dc.contributor.googleauthor | Won-Jae Lee | - |
dc.identifier.doi | 10.1126/science.1212782 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02604 | - |
dc.contributor.localId | A02522 | - |
dc.relation.journalcode | J02642 | - |
dc.identifier.eissn | 1095-9203 | - |
dc.identifier.pmid | 22053049 | - |
dc.contributor.alternativeName | Ryu, Ji Hwan | - |
dc.contributor.alternativeName | Yoon, Joo Heon | - |
dc.contributor.affiliatedAuthor | Yoon, Joo Heon | - |
dc.contributor.affiliatedAuthor | Ryu, Ji Hwan | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 334 | - |
dc.citation.number | 6056 | - |
dc.citation.startPage | 670 | - |
dc.citation.endPage | 674 | - |
dc.identifier.bibliographicCitation | SCIENCE, Vol.334(6056) : 670-674, 2011 | - |
dc.identifier.rimsid | 27335 | - |
dc.type.rims | ART | - |
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