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Clinical features and outcomes of acute kidney injury among patients with acute hepatitis A.

Authors
 Hee Kyoung Choi  ;  Young Goo Song  ;  Sang Hoon Han  ;  Nam Su Ku  ;  Su Jin Jeong  ;  Ji-hyeon Ba다  ;  Hyewon Kim  ;  Sun Bean Kim  ;  Chang Oh Kim  ;  June Myung Kim  ;  Jun Yong Choi 
Citation
 JOURNAL OF CLINICAL VIROLOGY, Vol.52(3) : 192-197, 2011 
Journal Title
JOURNAL OF CLINICAL VIROLOGY
ISSN
 1386-6532 
Issue Date
2011
MeSH
Acute Disease ; Acute Kidney Injury/etiology* ; Acute Kidney Injury/virology ; Adolescent ; Adult ; Aged ; Case-Control Studies ; Child ; Female ; Hepatitis A/complications* ; Hepatitis A/mortality ; Hepatitis A/pathology ; Hepatitis A/virology ; Hepatitis A Virus, Human/pathogenicity* ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Risk Factors ; Treatment Outcome
Keywords
Hepatitis A ; Acute kidney injury ; Acute renal failure
Abstract
BACKGROUND: Although acute hepatitis A is usually self-limited, the clinical manifestations can vary from mild to severe liver dysfunction. However, little is known about risk factors for and outcomes of acute kidney injury (AKI) in acute hepatitis A.

OBJECTIVES: To identify the risk factors for and outcomes of AKI in acute hepatitis A.

STUDY DESIGN: We identified 396 patients with acute hepatitis A, which registered between January 2006 and June 2009 at a tertiary care university hospital. Retrospective case-control studies were conducted in order to identify risk factors for AKI.

RESULTS: Thirty patients (7.6%) developed AKI. On multivariate analysis, fulminant hepatitis, leukocytosis, and elevated CRP were independent risk factors for AKI associated with hepatitis A, and higher total bilirubin, leukocytosis, and elevated CRP were independent risk factor for AKI within nonfulminant hepatitis A. Of the 30 patients with AKI, 23 (76.7%) patients fully recovered, 2 patients maintained hemodialysis after hospital discharge and 5 patients died due to hepatic failure without recovery from AKI. Among 20 patients with AKI in nonfulminant subgroup, 19 patients (95%) recovered without hemodialysis.

CONCLUSIONS: AKI is not a rare complication of acute hepatitis A and severity of hepatitis and hepatic injury influence the development of AKI in acute hepatitis A.
Full Text
http://www.sciencedirect.com/science/article/pii/S1386653211002885
DOI
10.1016/j.jcv.2011.07.013
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ku, Nam Su(구남수) ORCID logo https://orcid.org/0000-0002-9717-4327
Kim, Sun Bean(김선빈)
Kim, June Myung(김준명)
Kim, Chang Oh(김창오) ORCID logo https://orcid.org/0000-0002-0773-5443
Kim, Hye Won(김혜원)
Song, Young Goo(송영구) ORCID logo https://orcid.org/0000-0002-0733-4156
Jeong, Su Jin(정수진) ORCID logo https://orcid.org/0000-0003-4025-4542
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
Han, Sang Hoon(한상훈) ORCID logo https://orcid.org/0000-0002-4278-5198
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94432
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