Cited 8 times in
MyD88-dependent Toll-like receptor signaling is required for murine macrophages response to IS2
DC Field | Value | Language |
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dc.contributor.author | 유지환 | - |
dc.date.accessioned | 2014-12-20T17:20:52Z | - |
dc.date.available | 2014-12-20T17:20:52Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1567-5769 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/94430 | - |
dc.description.abstract | IS2, a soluble β-glucan isolated from the cell wall of mutated Saccharomyces cerevisiae (S. cerevisiae) enhances the immune response compared to the wild type (WT) β-glucan. In the present investigation we report that Toll-like receptor (TLR)/MyD88 signaling pathway was responsible in IS2 β-glucan-mediated cellular response in RAW264.7 murine macrophages. Data revealed that IS2 β-glucan significantly up-regulated the TLR2/TLR4 expression. Moreover, TLR2/TLR4 responds to IS2 resulting in murine macrophage activation. In addition, the IS2 signal led to cytokine secretions of IL-6 and TNF-α. In the case of thioglycolate-elicited peritoneal macrophages from MyD88-deficient mice, the decrease in cytokines was observed. Further the mitogen-activated protein kinases (MAPKs) phosphorylation was evident and degradation of IκB-α was increased after stimulation with IS2 β-glucan. Further examination with MyD88-deficient mice revealed that the MyD88 pathway might play an important role for IS2 β-glucan-mediated activation of macrophages. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1578~1583 | - |
dc.relation.isPartOf | INTERNATIONAL IMMUNOPHARMACOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cell Line | - |
dc.subject.MESH | Gene Expression Regulation/drug effects | - |
dc.subject.MESH | Gene Expression Regulation/immunology | - |
dc.subject.MESH | Interleukin-6/genetics | - |
dc.subject.MESH | Interleukin-6/metabolism | - |
dc.subject.MESH | Macrophage Activation/drug effects | - |
dc.subject.MESH | Macrophages/drug effects* | - |
dc.subject.MESH | Macrophages/immunology | - |
dc.subject.MESH | Macrophages/metabolism | - |
dc.subject.MESH | Macrophages/pathology | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Knockout | - |
dc.subject.MESH | Mitogen-Activated Protein Kinases/metabolism | - |
dc.subject.MESH | Mutation/genetics | - |
dc.subject.MESH | Myeloid Differentiation Factor 88/immunology | - |
dc.subject.MESH | Myeloid Differentiation Factor 88/metabolism | - |
dc.subject.MESH | Saccharomyces cerevisiae/genetics | - |
dc.subject.MESH | Saccharomyces cerevisiae/immunology* | - |
dc.subject.MESH | Signal Transduction/drug effects | - |
dc.subject.MESH | Signal Transduction/immunology | - |
dc.subject.MESH | Toll-Like Receptor 2/genetics | - |
dc.subject.MESH | Toll-Like Receptor 2/immunology | - |
dc.subject.MESH | Toll-Like Receptor 2/metabolism* | - |
dc.subject.MESH | Toll-Like Receptor 4/genetics | - |
dc.subject.MESH | Toll-Like Receptor 4/immunology | - |
dc.subject.MESH | Toll-Like Receptor 4/metabolism* | - |
dc.subject.MESH | Tumor Necrosis Factor-alpha/genetics | - |
dc.subject.MESH | Tumor Necrosis Factor-alpha/metabolism | - |
dc.subject.MESH | beta-Glucans/administration & dosage* | - |
dc.subject.MESH | beta-Glucans/isolation & purification | - |
dc.subject.MESH | beta-Glucans/pharmacology | - |
dc.title | MyD88-dependent Toll-like receptor signaling is required for murine macrophages response to IS2 | - |
dc.type | Article | - |
dc.contributor.college | Researcher Institutes (부설 연구소) | - |
dc.contributor.department | 생체방어연구센터 | - |
dc.contributor.googleauthor | Hua Li | - |
dc.contributor.googleauthor | Wan-Jae Kim | - |
dc.contributor.googleauthor | Jun Jiang | - |
dc.contributor.googleauthor | Seung-Hwan Lee | - |
dc.contributor.googleauthor | Hyung-Sun Youn | - |
dc.contributor.googleauthor | Eun-Yi Moon | - |
dc.contributor.googleauthor | Tack-Joong Kim | - |
dc.contributor.googleauthor | Sang-Kyu Ye | - |
dc.contributor.googleauthor | Ji-Hwan Ryu | - |
dc.contributor.googleauthor | Tae-Bong Kang | - |
dc.contributor.googleauthor | Sushruta Koppula | - |
dc.contributor.googleauthor | Pyo-Jam Park | - |
dc.contributor.googleauthor | Dong-Kug Choi | - |
dc.contributor.googleauthor | Kwang-Ho Lee | - |
dc.identifier.doi | 10.1016/j.intimp.2011.05.017 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02522 | - |
dc.relation.journalcode | J01081 | - |
dc.identifier.eissn | 1878-1705 | - |
dc.identifier.pmid | 21628003 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S1567576911002281 | - |
dc.subject.keyword | β-glucan | - |
dc.subject.keyword | IS2 | - |
dc.subject.keyword | TLR | - |
dc.subject.keyword | MyD88 | - |
dc.subject.keyword | MAPKs | - |
dc.contributor.alternativeName | Ryu, Ji Hwan | - |
dc.contributor.affiliatedAuthor | Ryu, Ji Hwan | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 11 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1578 | - |
dc.citation.endPage | 1583 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL IMMUNOPHARMACOLOGY, Vol.11(10) : 1578-1583, 2011 | - |
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