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Evaluation of algorithms for intracranial EEG (iEEG) source imaging of extended sources: feasibility of using iEEG source imaging for localizing epileptogenic zones in secondary generalized epilepsy.

Authors
 Jae-Hyun Cho  ;  Seung Bong Hong  ;  Young-Jin Jung  ;  Hoon-Chul Kang  ;  Heung Dong Kim  ;  Minah Suh  ;  Ki-Young Jung  ;  Chang-Hwan Im 
Citation
 BRAIN TOPOGRAPHY, Vol.24(2) : 91-104, 2011 
Journal Title
BRAIN TOPOGRAPHY
ISSN
 0896-0267 
Issue Date
2011
MeSH
Algorithms* ; Brain Mapping/methods ; Cerebral Cortex/pathology ; Child ; Child, Preschool ; Electroencephalography/methods* ; Epilepsy, Generalized/diagnosis* ; Epilepsy, Generalized/pathology ; Feasibility Studies ; Humans ; Intellectual Disability/diagnosis* ; Intellectual Disability/pathology ; Lennox Gastaut Syndrome ; Male ; Pattern Recognition, Automated/methods* ; Predictive Value of Tests ; Signal Processing, Computer-Assisted* ; Spasms, Infantile/diagnosis* ; Spasms, Infantile/pathology
Keywords
Cortical source imaging ; Localization of epileptogenic zone ; Lennox-Gastaut syndrome ; Intracranial electroencephalography ; Ictal epileptiform activity ; Inverse problem
Abstract
Precise identification of epileptogenic zones in patients with intractable drug-resistant epilepsy is critical for successful epilepsy surgery. Numerous source-imaging algorithms for localizing epileptogenic zones based on scalp electroencephalography (EEG) and magnetoencephalography (MEG) have been developed and validated in simulation and experimental studies. Recently, intracranial EEG (iEEG)-based imaging of epileptogenic sources has attracted interest as a promising tool for presurgical evaluation of epilepsy; however, most iEEG studies have focused on localization of epileptogenic zones in focal epilepsy. In the present study, we investigated whether iEEG source imaging is a useful supplementary tool for identifying extended epileptogenic sources in secondary generalized epilepsy such as Lennox-Gastaut syndrome (LGS). To this end, we applied four different cortical source imaging algorithms, namely minimum norm estimation (MNE), low-resolution electromagnetic tomography (LORETA), standardized LORETA (sLORETA), and L(p)-norm estimation (p = 1.5, referred to as Lp1.5), to artificial iEEG datasets generated assuming various source sizes and locations. We also applied these four algorithms to clinical ictal iEEG recordings acquired from a pediatric patient with LGS. Interestingly, the traditional MNE algorithm outperformed the other imaging algorithms in most of our experiments, particularly in cases when larger-sized sources were activated. Although sLORETA outperformed both LORETA and Lp1.5, its performance was not as good as that of MNE. Compared to the other algorithms, the performance of Lp1.5 decayed most rapidly as the source size increased. Our findings suggest that iEEG source imaging using MNE is a promising auxiliary tool for the identification of epileptogenic zones in secondary generalized epilepsy. We anticipate that our results will provide useful guidelines for selection of an appropriate imaging algorithm for iEEG source imaging studies.
Full Text
http://link.springer.com/article/10.1007%2Fs10548-011-0173-2
DOI
10.1007/s10548-011-0173-2
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Hoon Chul(강훈철) ORCID logo https://orcid.org/0000-0002-3659-8847
Kim, Heung Dong(김흥동) ORCID logo https://orcid.org/0000-0002-8031-7336
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94418
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