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A topical Chinese herbal mixture improves epidermal permeability barrier function in normal murine skin

Authors
 Mona Man  ;  Melanie Hupe  ;  Donald Mackenzie  ;  Hyunjung Kim  ;  Yuko Oda  ;  Debra Crumrine  ;  Seung Hun Lee  ;  Gemma Martin-Ezquerra  ;  Carles Trullas  ;  Theodora M. Mauro  ;  Kenneth R. Feingold  ;  Peter M. Elias  ;  Mao-Qiang Man 
Citation
 EXPERIMENTAL DERMATOLOGY, Vol.20(3) : 285-288, 2011 
Journal Title
EXPERIMENTAL DERMATOLOGY
ISSN
 0906-6705 
Issue Date
2011
MeSH
ATP-Binding Cassette Transporters/genetics ; Amidohydrolases/genetics ; Animals ; Antimicrobial Cationic Peptides/genetics ; Antimicrobial Cationic Peptides/metabolism ; Drugs,ChineseHerbal/isolation & purification ; Drugs,ChineseHerbal/pharmacology* ; Epidermis/cytology ; Epidermis/drug effects* ; Epidermis/metabolism ; Female ; Gene Expression/drug effects ; Gene Expression/genetics ; Humans ; Keratinocytes/drug effects ; Keratinocytes/metabolism ; Lipid Metabolism/drug effects ; Mice ; Mice, Hairless ; Permeability/drug effects* ; Secretory Vesicles/metabolism ; Serine C-Palmitoyltransferase/genetics ; Skin/cytology ; Skin/drug effects* ; Skin/metabolism ; Up-Regulation/genetics ; beta-Defensins/genetics ; beta-Defensins/metabolism
Keywords
barrier function ; cathelicidin antimicrobial peptide ; dermatitis ;  ; herbal medicine ; β defensin
Abstract
Chinese herbal medicine (CHM) has been shown to have beneficial effects for both skin disorders with barrier abnormality and as skin care ingredients. Yet, how CHM exerts their benefits is unclear. As most, if not all, inflammatory dermatoses are accompanied by abnormal permeability barrier function, we assessed the effects of topical CHM extracts on epidermal permeability barrier function and their potential mechanisms. Topical CHM accelerated barrier recovery following acute barrier disruption. Epidermal lipid content and mRNA expression of fatty acid and ceramide synthetic enzymes increased following topical CHM treatment in addition to mRNA levels for the epidermal glucosylceramide transport protein, ATP-binding cassette A12. Likewise, CHM extract increased mRNA expression of antimicrobial peptides both in vivo and in vitro. These results demonstrate that the topical CHM extract enhances epidermal permeability barrier function, suggesting that topical CHM could provide an alternative regimen for the prevention/treatment of inflammatory dermatoses accompanied by barrier abnormalities.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0625.2010.01205.x/abstract
DOI
10.1111/j.1600-0625.2010.01205.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyun Jung(김현정)
Lee, Seung Hun(이승헌)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94355
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