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Antifibrotic effects of magnesium lithospermate B on hepatic stellate cells and thioacetamide-induced cirrhotic rats.

DC Field Value Language
dc.contributor.author김자경-
dc.contributor.author백용한-
dc.contributor.author윤영준-
dc.contributor.author이관식-
dc.contributor.author이현철-
dc.contributor.author정숙인-
dc.contributor.author조재용-
dc.contributor.author한광협-
dc.date.accessioned2014-12-20T17:17:58Z-
dc.date.available2014-12-20T17:17:58Z-
dc.date.issued2011-
dc.identifier.issn1226-3613-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/94336-
dc.description.abstractMagnesium lithospermate B (MLB) is one of the major active components of Salvia miltiorrhizae. The anti-oxidative effects of Salvia miltiorrhizae have been previously reported. The aim of this study was to investigate the effect of purified MLB on hepatic fibrosis in rats and on the fibrogenic responses in hepatic stellate cells (HSCs). Hepatic fibrosis was induced in rats by intraperitoneal thioacetamide (TAA) injections over a period of 8 or 12 weeks. MLB was orally administered daily by gavage tube. Serum AST and ALT levels in TAA+ MLB group were significantly lower than those in TAA only group at week 8. Hepatic fibrosis was significantly attenuated in TAA+MLB group than in TAA only group at week 8 or 12. Activation of HSCs was also decreased in TAA+MLB group as compared to TAA only group. Hepatic mRNA expression of α-smooth muscle actin (α-SMA), TGF-β1, and collagen α1(I) was significantly decreased in TAA+MLB group as compared to TAA only group. Incubation with HSCs and MLB (>or=100 μM) for up to 48 h showed no cytotoxicity. MLB suppressed PDGF-induced HSC proliferation. MLB inhibited NF-ΚB transcriptional activation and monocyte chemotactic protein 1 (MCP-1) production in HSCs. MLB strongly suppressed H(2)O(2)-induced reactive oxygen species (ROS) generation in HSCs, and MLB inhibited type I collagen secretion in HSCs. We concluded that MLB has potent antifibrotic effect in TAA-treated cirrhotic rats, and inhibits fibrogenic responses in HSCs. These data suggest that MLB has potential as a novel therapy for hepatic fibrosis.-
dc.description.statementOfResponsibilityopen-
dc.format.extent341~349-
dc.relation.isPartOfEXPERIMENTAL AND MOLECULAR MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHActins/genetics-
dc.subject.MESHActins/metabolism-
dc.subject.MESHAnimals-
dc.subject.MESHAntioxidants/administration & dosage*-
dc.subject.MESHCell Proliferation/drugeffects-
dc.subject.MESHCollagen Type I/genetics-
dc.subject.MESHCollagen Type I/metabolism-
dc.subject.MESHDrugs, Chinese Herbal/administration & dosage*-
dc.subject.MESHFibrosis/prevention & control-
dc.subject.MESHHepaticStellateCells/drugeffects*-
dc.subject.MESHHepaticStellateCells/metabolism-
dc.subject.MESHHepaticStellateCells/pathology-
dc.subject.MESHLiver/drugeffects*-
dc.subject.MESHLiver/metabolism-
dc.subject.MESHLiver/pathology-
dc.subject.MESHLiver Cirrhosis, Experimental/chemically induced-
dc.subject.MESHLiver Cirrhosis, Experimental/drug therapy*-
dc.subject.MESHLiver Cirrhosis, Experimental/physiopathology-
dc.subject.MESHMale-
dc.subject.MESHNF-kappaB/metabolism-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHReactive Oxygen Species/metabolism-
dc.subject.MESHSalvia miltiorrhiza/immunology-
dc.subject.MESHThioacetamide/administration & dosage-
dc.subject.MESHTranscriptional Activation/drugeffects-
dc.titleAntifibrotic effects of magnesium lithospermate B on hepatic stellate cells and thioacetamide-induced cirrhotic rats.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorYong-Han Paik-
dc.contributor.googleauthorYoung Joon Yoon-
dc.contributor.googleauthorHyun Chul Lee-
dc.contributor.googleauthorMan Kil Jung-
dc.contributor.googleauthorSo Hee Kang-
dc.contributor.googleauthorSook In Chung-
dc.contributor.googleauthorJa Kyung Kim-
dc.contributor.googleauthorJae Yong Cho-
dc.contributor.googleauthorKwan Sik Lee-
dc.contributor.googleauthorKwang-Hyub Han-
dc.identifier.doi10.3858/emm.2011.43.6.037-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00852-
dc.contributor.localIdA01829-
dc.contributor.localIdA02582-
dc.contributor.localIdA02666-
dc.contributor.localIdA03301-
dc.contributor.localIdA03640-
dc.contributor.localIdA03899-
dc.contributor.localIdA04268-
dc.relation.journalcodeJ00860-
dc.identifier.eissn2092-6413-
dc.identifier.pmid21499011-
dc.subject.keywordantifibrotic therapy-
dc.subject.keywordcollagen-
dc.subject.keywordhepatic fibrosis-
dc.subject.keywordhepatic stellate cell-
dc.subject.keywordmagnesium lithospermate B-
dc.subject.keywordreactive oxygen species-
dc.contributor.alternativeNameKim, Ja Kyung-
dc.contributor.alternativeNamePaik, Yong Han-
dc.contributor.alternativeNameYoon, Young Joon-
dc.contributor.alternativeNameLee, Kwan Sik-
dc.contributor.alternativeNameLee, Hyun Chul-
dc.contributor.alternativeNameChung, Sook In-
dc.contributor.alternativeNameCho, Jae Yong-
dc.contributor.alternativeNameHan, Kwang Hyup-
dc.contributor.affiliatedAuthorKim, Ja Kyung-
dc.contributor.affiliatedAuthorPaik, Yong Han-
dc.contributor.affiliatedAuthorYoon, Young Joon-
dc.contributor.affiliatedAuthorLee, Kwan Sik-
dc.contributor.affiliatedAuthorLee, Hyun Chul-
dc.contributor.affiliatedAuthorChung, Sook In-
dc.contributor.affiliatedAuthorCho, Jae Yong-
dc.contributor.affiliatedAuthorHan, Kwang Hyup-
dc.rights.accessRightsfree-
dc.citation.volume43-
dc.citation.number6-
dc.citation.startPage341-
dc.citation.endPage349-
dc.identifier.bibliographicCitationEXPERIMENTAL AND MOLECULAR MEDICINE, Vol.43(6) : 341-349, 2011-
dc.identifier.rimsid27553-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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