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Associations between cardio-ankle vascular index and microvascular complications in type 2 diabetes mellitus patients

 Kwang Joon Kim  ;  Byung-Wan Lee  ;  Hyun Chul Lee  ;  Sung-Kil Lim  ;  Eun Jig Lee  ;  Bong Soo Cha  ;  Eun Seok Kang  ;  Joo youn Shin  ;  Hyun-min Kim 
 Journal of Atherosclerosis and Thromobosis, Vol.18(4) : 328-336, 2011 
Journal Title
 Journal of Atherosclerosis and Thromobosis 
Issue Date
AIM: Type 2 diabetes mellitus (T2DM) is a risk factor for increased arterial stiffness. We evaluated associations between the cardio-ankle vascular index (CAVI) and carotid plaque, intima media thickness (IMT), and diabetic microvascular complications in Korean T2DM patients. METHODS: We conducted a retrospective, cross-sectional study of 320 Korean T2DM patients without a history of macrovascular disease or macroalbuminuria. We measured 24-hour urinary albumin excretion (UAE) levels and performed funduscopic and neuropathy examinations to assess the extent of diabetic microvascular complications. Arterial stiffness was assessed using CAVI. We also measured the ankle-brachial index (ABI), common carotid artery IMT, and carotid beta stiffness index. RESULTS: Among the 320 patients enrolled in this study, 64 (20%) had increased CAVI (≥ 9). We found that CAVI was correlated with systolic blood pressure, pulse pressure, IMT, carotid beta stiffness index, log-transformed UAE, and total cholesterol. In multiple logistic regression analysis, mean IMT and the presence of carotid plaque were independently associated with increased CAVI (≥ 9) (OR=5.77, P < 0.01; OR=5.36, P < 0.001, respectively). Furthermore, an increased CAVI was associated with peripheral neuropathy (OR=2.03, P = 0.03) and microalbuminuria (OR=2.47, P < 0.01) after adjusting for possible confounding variables. CONCLUSIONS: The results of this study suggest that increased CAVI is associated with the presence of arterial plaque, increased IMT, and microvascular complications, such as nephropathy and neuropathy, in T2DM patients.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
강은석(Kang, Eun Seok) ; 김현민(Kim, Hyun Min) ; 이병완(Lee, Byung Wan) ; 이은직(Lee, Eun Jig) ; 이현철(Lee, Hyun Chul) ; 임승길(Lim, Sung Kil) ; 차봉수(Cha, Bong Soo)
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