3 453

Cited 3 times in

Carotid atheromatic plaque is commonly associated with hypopituitary men

Authors
 Joo Young Kim  ;  Jae Won Hong  ;  Sang Youl Rhee  ;  Chul Sik Kim  ;  Dae Jung Kim  ;  Eun Jig Lee 
Citation
 PITUITARY, Vol.14(2) : 105-111, 2011 
Journal Title
PITUITARY
ISSN
 1386-341X 
Issue Date
2011
MeSH
Adenoma/complications ; Adenoma/epidemiology ; Adult ; Aged ; CarotidArtery Diseases/complications ; CarotidArtery Diseases/epidemiology* ; Case-Control Studies ; Comorbidity ; Humans ; Hypopituitarism/complications ; Hypopituitarism/epidemiology* ; Male ; Middle Aged ; Pituitary Neoplasms/complications ; Pituitary Neoplasms/epidemiology ; Plaque, Atherosclerotic/complications ; Plaque, Atherosclerotic/epidemiology* ; Testosterone/blood ; Waist Circumference/physiology
Keywords
Hypopituitarism ; Carotid atheromatic plaque ; Low serum testosterone ; Central obesity
Abstract
Hypopituitarism increases the risks of many cardiovascular conditions and therefore, patients with this disease are more prone to cardiovascular disease. To our knowledge, there have been few studies on carotid artery plaque in male patients with hypopituitarism in assessing cardiovascular risks. The aim of this study was to specifically compare carotid artery plaque while examining other major cardiovascular risk factors between male patients with hypopituitarism and control subjects. Forty male patients aged 30-70 years with hypopituitarism and forty age, sex- matched control subjects were recruited at the Yonsei University Severance Hospital, Seoul, Korea. Carotid intima media thickness (IMT) and atheromatous plaque, anthropometry, lipid profile, and pituitary hormones were assessed. Atheromatous plaque in the carotid arteries was observed more frequently in patients with hypopituitarism than age- and sex-matched control subjects (59.5% vs. 2.5%, P<0.01) without differences of carotid IMTs. Patients with hypopituitarism also exhibited higher waist circumference, waist to hip ratio, total cholesterol and LDL cholesterol than control subjects. In subgroup analysis in male patients with hypopituitarism including GH deficiency, lower testosterone levels were associated with higher waist circumference (r=0.446, P=0.033). In conclusion, hypopituitary males exhibit an increased incidence of carotid artery plaque without differences of carotid IMTs, central obesity and higher total cholesterol level. Lower testosterone levels were associated with central obesity- a strong component of a metabolic syndrome, and unsubstituted testosterone deficiency might be an important cardiovascular risk factor in patients with hypopituitarism.
Full Text
http://link.springer.com/article/10.1007%2Fs11102-010-0265-0
DOI
10.1007/s11102-010-0265-0
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Joo Young(김주영)
Lee, Eun Jig(이은직) ORCID logo https://orcid.org/0000-0002-9876-8370
Hong, Jae Won(홍재원)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94324
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links