Cited 24 times in
Induction of bone formation by Escherichia coli-expressed recombinant human bone morphogenetic protein-2 using block-type macroporous biphasic calcium phosphate in orthotopic and ectopic rat mod
DC Field | Value | Language |
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dc.contributor.author | 김창성 | - |
dc.contributor.author | 박정철 | - |
dc.contributor.author | 정임희 | - |
dc.contributor.author | 조규성 | - |
dc.contributor.author | 최성호 | - |
dc.date.accessioned | 2014-12-20T17:12:22Z | - |
dc.date.available | 2014-12-20T17:12:22Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0022-3484 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/94157 | - |
dc.description.abstract | BACKGROUND AND OBJECTIVE: The potential of the Escherichia coli-expressed recombinant human bone morphogenetic protein-2 (ErhBMP-2) to support new bone formation/maturation using a block-type of macroporous biphasic calcium phosphate (bMBCP) carrier was evaluated in an orthotopic and ectopic rat model. MATERIAL AND METHODS: Critical-size (Φ 8 mm) calvarial defects and subcutaneous pockets in 32 Sprague-Dawley rats received implants of rhBMP-2 (2.5 μg) in a bMBCP carrier or bMBCP alone (control). Implant sites were evaluated using histological and histometric analysis following 2- and 8-wk healing intervals (eight animals/group/interval). Results: ErhBMP-2/bMBCP supported significantly greater bone formation at 2 and 8 wk (10.8% and 25.4%, respectively) than the control at 2 and 8 wk (5.3% and 14.0%, respectively) in calvarial defects (p < 0.01). Bone formation was only observed for the ErhBMP-2/bMBCP ectopic sites and was significantly greater at 8 wk (7.5%) than at 2 wk (4.5%) (p < 0.01). Appositional and endochondral bone formation was usually associated with a significant increase in fatty marrow at 8 wk. The bMBCP carrier showed no evidence of bioresorption. CONCLUSION: ErhBMP-2/bMBCP induced significant bone formation in both calvarial and ectopic sites. Further study appears to be required to evaluate the relevance of the bMBCP carrier. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 682~690 | - |
dc.relation.isPartOf | JOURNAL OF PERIODONTAL RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adipogenesis/drug effects | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Bone Morphogenetic Protein 2/biosynthesis | - |
dc.subject.MESH | Bone Morphogenetic Protein 2/pharmacology* | - |
dc.subject.MESH | Bone Substitutes* | - |
dc.subject.MESH | Escherichia coli/metabolism | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hydroxyapatites* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Models, Animal | - |
dc.subject.MESH | Osteogenesis/drug effects* | - |
dc.subject.MESH | Porosity | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Recombinant Proteins/biosynthesis | - |
dc.subject.MESH | Recombinant Proteins/pharmacology | - |
dc.subject.MESH | Skull/surgery | - |
dc.subject.MESH | Subcutaneous Tissue/surgery | - |
dc.subject.MESH | Tissue Scaffolds* | - |
dc.title | Induction of bone formation by Escherichia coli-expressed recombinant human bone morphogenetic protein-2 using block-type macroporous biphasic calcium phosphate in orthotopic and ectopic rat mod | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Periodontology (치주과학) | - |
dc.contributor.googleauthor | J-C. Park | - |
dc.contributor.googleauthor | S-S. So | - |
dc.contributor.googleauthor | I-H. Jung | - |
dc.contributor.googleauthor | J-H. Yun | - |
dc.contributor.googleauthor | S-H. Choi | - |
dc.contributor.googleauthor | K-S. Cho | - |
dc.contributor.googleauthor | C-S. Kim | - |
dc.identifier.doi | 10.1111/j.1600-0765.2011.01390.x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01041 | - |
dc.contributor.localId | A01653 | - |
dc.contributor.localId | A03810 | - |
dc.contributor.localId | A04081 | - |
dc.contributor.localId | A03703 | - |
dc.relation.journalcode | J01696 | - |
dc.identifier.eissn | 1600-0765 | - |
dc.identifier.pmid | 21702756 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0765.2011.01390.x/abstract | - |
dc.subject.keyword | animal model | - |
dc.subject.keyword | bone grafting | - |
dc.subject.keyword | growth factors | - |
dc.contributor.alternativeName | Kim, Chang Sung | - |
dc.contributor.alternativeName | Park, Jung Chul | - |
dc.contributor.alternativeName | Jung, Im Hee | - |
dc.contributor.alternativeName | Cho, Kyoo Sung | - |
dc.contributor.alternativeName | Choi, Seong Ho | - |
dc.contributor.affiliatedAuthor | Kim, Chang Sung | - |
dc.contributor.affiliatedAuthor | Park, Jung Chul | - |
dc.contributor.affiliatedAuthor | Cho, Kyoo Sung | - |
dc.contributor.affiliatedAuthor | Choi, Seong Ho | - |
dc.contributor.affiliatedAuthor | Jung, Im Hee | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 46 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 682 | - |
dc.citation.endPage | 690 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PERIODONTAL RESEARCH, Vol.46(6) : 682-690, 2011 | - |
dc.identifier.rimsid | 27280 | - |
dc.type.rims | ART | - |
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