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Polymorphisms in GSDMA and GSDMB are associated with asthma susceptibility, atopy and BHR

 Jinho Yu  ;  Mi-Jin Kang  ;  Byoung-Ju Kim  ;  Ji-Won Kwon MD  ;  Young-Hwa Song MD  ;  Won-Ah Choi MS  ;  Yee-Jin Shin MD, PhD  ;  Soo-Jong Hong MD, PhD 
 PEDIATRIC PULMONOLOGY, Vol.46(7) : 701-708, 2011 
Journal Title
Issue Date
Asthma/genetics* ; Case-Control Studies ; Child ; Female ; Genetic Predisposition to Disease* ; Genotype ; Haplotypes ; Humans ; Hypersensitivity, Immediate/genetics* ; Immunoglobulin E/blood ; Male ; Neoplasm Proteins/genetics* ; Phenotype ; Polymorphism, Single Nucleotide/genetics* ; Republic of Korea ; Respiratory Hypersensitivity/genetics*
asthma bronchial ; hyperresponsiveness ; GSDMA ; GSDMB ; IgE
The gasdermin A (GSDMA) and gasdermin B (GSDMB) genes are located at 17q21.2. The GSDM family genes have been studied in the gastrointestinal tract but recent reports suggest that GSDMB is associated with childhood asthma in several populations. We investigated the association of the GSDMA and GSDMB variants with asthma in Korean children, and to assess the effect of these variants on intermediate phenotypes of asthma. Asthmatic (n = 778) and normal (n = 522) children were enrolled and genotypes were determined using PCR-RFLP. Asthma susceptibility was associated with GG of the GSDMA (rs7212938) and TT of GSDMB (rs7216389). And a combination of risk alleles of two polymorphisms was associated with asthma susceptibility and a frequency of those was higher in asthmatic children with increased levels of total IgE (aOR 1.77, 95% CI 1.15-2.72) and BHR (aOR 1.54, 95% CI 0.99-2.40) compared to normal. Also, we observed a significant association between haplotype of two polymorphisms and asthma susceptibility. The region including the GSDMA and GSDMB polymorphisms may be associated with asthma susceptibility and intermediate phenotypes of asthma, such as elevated IgE and BHR, in Korean children with asthma. These results strongly support an important role for the GSDMA and GSDMB in the development of childhood asthma.
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1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Shin, Yee Jin(신의진) ORCID logo https://orcid.org/0000-0001-8573-4342
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