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Prospective evaluation of the clinical utility of interferon-γ assay in the differential diagnosis of intestinal tuberculosis and Crohn's disease.

 Beom Jin Kim ; Yong Sung Choi ; Young-Ho Kim ; Suk-Kyun Yang ; Byong Duk Ye ; Jae Hee Cheon ; Yoon Tae Jeen ; Chang Hwan Choi ; Jai Hyun Choi ; Joo Sung Kim ; Dong Soo Han ; Sung-Ae Jung ; You Sun Kim ; Won Ho Kim ; Young Sook Park ; Byung Ik Jang 
 Inflammatory Bowel Diseases, Vol.17(6) : 1308~1313, 2011 
Journal Title
 Inflammatory Bowel Diseases 
Issue Date
utility of the QuantiFERON-TB gold test (QFT) in the differential diagnosis of ITB and CD, and compared it with the clinical utility of the tuberculin skin test (TST). METHODS: Patients with suspected ITB or CD on colonoscopic findings were enrolled from 13 hospitals in Korea between June 2007 and November 2008. A QFT and TST were performed. When the initial diagnosis was not confirmed, 2-3 months of empiric antituberculous therapy was administered. RESULTS: In all, 128 patients were analyzed; 64 patients had ITB and 64 patients had CD. The median age of patients with ITB was greater than the patients with CD (47 years versus 31 years, P < 0.001). The positive rate for the QFT and TST (≥10 mm) in patients with ITB was significantly higher than patients with CD (67% versus 9% and 69% versus 16%, respectively; P < 0.001). The QFT and TST had good agreement (κ = 0.724, P < 0.001). The diagnostic validity of QFT in ITB had a 67% sensitivity, 90% specificity, 87% positive predictive value, and 73% negative predictive value. There was no difference in these parameters between the QFT and TST. The likelihood ratio for a positive QFT was higher than a positive TST in the diagnosis of ITB (7.1 and 4.4, respectively). CONCLUSIONS: The QFT is a limited but useful diagnostic aid in combination with the TST in the diagnosis of ITB
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