2 486

Cited 15 times in

Radiosensitizers in hepatocellular carcinoma

Authors
 Ik Jae Lee  ;  Jinsil Seong 
Citation
 SEMINARS IN RADIATION ONCOLOGY, Vol.21(4) : 303-311, 2011 
Journal Title
SEMINARS IN RADIATION ONCOLOGY
ISSN
 1053-4296 
Issue Date
2011
MeSH
Carcinoma, Hepatocellular/radiotherapy* ; Humans ; Liver Neoplasms/radiotherapy* ; Radiation-Sensitizing Agents/therapeutic use*
Abstract
Most hepatocellular carcinoma (HCC) patients present with locally advanced disease with a risk of development of intrahepatic or extrahepatic metastases. Conformal radiotherapy (RT) can be delivered to focal HCCs with sustained local control in selected HCC patients. However, it is frequently not possible to deliver tumoricidal doses to locally advanced HCC due to the risk of radiation-induced liver toxicity or the risk of toxicity to adjacent luminal gastrointestinal organs. Combining RT with radiosensitizers is an attractive strategy to increase the therapeutic ratio for these patients. Clinical experience in combining RT and radiosensitizers in HCC is limited. Hepatic arterial chemoembolization (or transcatheter arterial chemoembolization, TACE) has been used in combination with RT for the treatment of HCC, as have halogenated pyrimidines. More recently, there is a growing experience of RT delivered with molecular targeted agents in HCC. In this review, the rationale for potential radiation sensitization and the clinical experience in HCC for different classes of radiation sensitizers are discussed.
Full Text
http://www.sciencedirect.com/science/article/pii/S1053429611000506
DOI
10.1016/j.semradonc.2011.05.008
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Seong, Jin Sil(성진실) ORCID logo https://orcid.org/0000-0003-1794-5951
Lee, Ik Jae(이익재) ORCID logo https://orcid.org/0000-0001-7165-3373
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94077
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links