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Risk assessment of hepatitis B virus-related hepatocellular carcinoma development using liver stiffness measurement (FibroScan).

Authors
 Kyu Sik Jung  ;  Seung Up Kim  ;  Sang Hoon Ahn  ;  Young Nyun Park  ;  Do Young Kim  ;  Jun Yong Park  ;  Chae Yoon Chon  ;  Eun Hee Choi  ;  Kwang-Hyub Han 
Citation
 HEPATOLOGY, Vol.53(3) : 885-894, 2011 
Journal Title
HEPATOLOGY
ISSN
 0270-9139 
Issue Date
2011
MeSH
Adult ; Aged ; Aged, 80 and over ; Carcinoma, Hepatocellular/virology* ; Elasticity Imaging Techniques* ; Female ; Hepatitis B, Chronic/complications* ; Hepatitis B, Chronic/pathology ; Hepatitis C, Chronic/epidemiology ; Hepatitis C, Chronic/etiology ; Hepatitis C, Chronic/pathology ; Humans ; Incidence ; Liver/pathology* ; Liver Neoplasms/virology* ; Male ; Middle Aged ; Prospective Studies ; Republic of Korea/epidemiology ; Risk Assessment
Abstract
Liver stiffness measurement (LSM) using FibroScan accurately assesses the degree of liver fibrosis and the risk of hepatocellular carcinoma (HCC) development in patients with chronic hepatitis C. This study investigated the usefulness of LSM as a predictor of HCC development in patients with chronic hepatitis B (CHB). A total of 1,130 patients with non-biopsy-proven CHB who underwent LSM between May 2005 and December 2007 were enrolled in this prospective study. After LSM was performed, patients attended regular follow-up as part of a surveillance program for the detection of HCC. The mean age of the patients (767 men, 363 women) was 50.2 years, and the median LSM was 7.7 kPa. Six hundred seventy-two (59.5%) patients received antiviral treatment before or after enrollment. During the follow-up period (median, 30.7 months; range, 24.0-50.9 months), HCC developed in 57 patients (2.0% per 1 person-year). The 1-, 2-, and 3-year cumulative incidence rates of HCC were 0.80%, 3.26%, and 5.98%, respectively. On multivariate analysis, together with old age, male sex, heavy alcohol consumption (>80 g/day), serum albumin, and hepatitis B e antigen positivity, patients with a higher LSM (>8 kPa) were at a significantly greater risk of HCC development, with the following hazard ratios: 3.07 (95% confidence interval [CI], 1.01-9.31; P = 0.047) for LSM 8.1-13 kPa; 4.68 (95% CI, 1.40-15.64; P = 0.012) for LSM 13.1-18 kPa; 5.55 (95% CI, 1.53-20.04; P = 0.009) for LSM 18.1-23 kPa; and 6.60 (95% CI, 1.83-23.84; P = 0.004) for LSM >23 kPa.

CONCLUSION: Our data suggest that LSM could be a useful predictor of HCC development in patients with CHB.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/hep.24121/abstract
DOI
10.1002/hep.24121
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Do Young(김도영)
Kim, Seung Up(김승업) ORCID logo https://orcid.org/0000-0002-9658-8050
Park, Young Nyun(박영년) ORCID logo https://orcid.org/0000-0003-0357-7967
Park, Jun Yong(박준용) ORCID logo https://orcid.org/0000-0001-6324-2224
Ahn, Sang Hoon(안상훈) ORCID logo https://orcid.org/0000-0002-3629-4624
Chon, Chae Yoon(전재윤)
Jung, Kyu Sik(정규식)
Choi, Eun Hee(최은희)
Han, Kwang-Hyub(한광협) ORCID logo https://orcid.org/0000-0003-3960-6539
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94064
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