Cited 71 times in
Vascular tube formation and angiogenesis induced by polyvinylpyrrolidone-coated silver nanoparticles
DC Field | Value | Language |
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dc.contributor.author | 최인홍 | - |
dc.date.accessioned | 2014-12-20T17:06:56Z | - |
dc.date.available | 2014-12-20T17:06:56Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0378-4274 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/93990 | - |
dc.description.abstract | Silver nanoparticles (AgNPs) are one of the most commonly used nanomaterials due to their antibacterial properties. In this study, we examined the effects of polyvinylpyrrolidone (PVP)-coated AgNPs (average size 2.3nm) on angiogenesis in both an in vivo model and an in vitro endothelial cell line, SVEC4-10. Increased angiogenesis was detected around the injection site of AgNP-containing Matrigel in vivo. AgNPs also increased the infiltration of endothelial cells and the hemoglobin (Hb) content in AgNP-Matrigel plugs implanted into mice. AgNPs induced endothelial cell tube formation on growth factor-reduced Matrigel, production of reactive oxygen species (ROS), and production of angiogenic factors, such as vascular endothelial growth factor (VEGF) and nitric oxide (NO), in SVEC4-10 cells. In addition, AgNPs promoted the activation of FAK, Akt, ERK1/2, and p38, which are all involved in VEGF receptor (VEGFR)-mediated signaling. Finally, AgNP-treated tumors caused angiogenesis around tumors in B16F10 melanomas after they were injected into mice, and the Hb concentration in the tumors increased in a concentration-dependent manner with AgNP treatment. Thus, our study suggests that exposure to AgNPs can cause angiogenesis through the production of angiogenic factors. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 227~234 | - |
dc.relation.isPartOf | TOXICOLOGY LETTERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cell Line | - |
dc.subject.MESH | Drug Implants | - |
dc.subject.MESH | Endothelium, Vascular/drug effects* | - |
dc.subject.MESH | Endothelium, Vascular/metabolism | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Hemoglobins/metabolism | - |
dc.subject.MESH | Melanoma, Experimental/blood supply | - |
dc.subject.MESH | Melanoma, Experimental/metabolism | - |
dc.subject.MESH | Metal Nanoparticles/administration & dosage | - |
dc.subject.MESH | Metal Nanoparticles/chemistry | - |
dc.subject.MESH | Metal Nanoparticles/toxicity* | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred C57BL | - |
dc.subject.MESH | Neovascularization, Pathologic/chemically induced* | - |
dc.subject.MESH | Neovascularization, Pathologic/metabolism | - |
dc.subject.MESH | Nitric Oxide/metabolism | - |
dc.subject.MESH | Particle Size | - |
dc.subject.MESH | Povidone/administration & dosage | - |
dc.subject.MESH | Povidone/chemistry | - |
dc.subject.MESH | Povidone/toxicity* | - |
dc.subject.MESH | Reactive Oxygen Species/metabolism | - |
dc.subject.MESH | Receptors, Vascular Endothelial Growth Factor/metabolism | - |
dc.subject.MESH | Signal Transduction/drug effects | - |
dc.subject.MESH | Silver/administration & dosage | - |
dc.subject.MESH | Silver/chemistry | - |
dc.subject.MESH | Silver/toxicity* | - |
dc.subject.MESH | Subcutaneous Tissue/blood supply | - |
dc.subject.MESH | Subcutaneous Tissue/drug effects | - |
dc.subject.MESH | Subcutaneous Tissue/metabolism | - |
dc.subject.MESH | Subcutaneous Tissue/pathology | - |
dc.subject.MESH | Surface Properties | - |
dc.subject.MESH | Vascular Endothelial Growth Factors/metabolism | - |
dc.title | Vascular tube formation and angiogenesis induced by polyvinylpyrrolidone-coated silver nanoparticles | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학) | - |
dc.contributor.googleauthor | Kyeongah Kang | - |
dc.contributor.googleauthor | Dae-Hyoun Lim | - |
dc.contributor.googleauthor | In-Hong Choi | - |
dc.contributor.googleauthor | Taegyeong Kang | - |
dc.contributor.googleauthor | Kangtaek Lee | - |
dc.contributor.googleauthor | Eun-Yi Moon | - |
dc.contributor.googleauthor | Young Yang | - |
dc.contributor.googleauthor | Myeong-Sok Lee | - |
dc.contributor.googleauthor | Jong-Seok Lim | - |
dc.identifier.doi | 10.1016/j.toxlet.2011.05.1033 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04167 | - |
dc.relation.journalcode | J02744 | - |
dc.identifier.eissn | 1879-3169 | - |
dc.identifier.pmid | 21729742 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0378427411012513 | - |
dc.subject.keyword | Silver nanoparticles | - |
dc.subject.keyword | Matrigel plug | - |
dc.subject.keyword | Angiogenesis | - |
dc.subject.keyword | Vascular endothelial growth factor | - |
dc.subject.keyword | VEGF signaling | - |
dc.contributor.alternativeName | Choi, In Hong | - |
dc.contributor.affiliatedAuthor | Choi, In Hong | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 205 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 227 | - |
dc.citation.endPage | 234 | - |
dc.identifier.bibliographicCitation | TOXICOLOGY LETTERS, Vol.205(3) : 227-234, 2011 | - |
dc.identifier.rimsid | 28598 | - |
dc.type.rims | ART | - |
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