Cited 44 times in
Zinc stimulates tau S214 phosphorylation by the activation of Raf/mitogen-activated protein kinase-kinase/extracellular signal-regulated kinase pathway
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김철훈 | - |
dc.date.accessioned | 2014-12-20T17:06:48Z | - |
dc.date.available | 2014-12-20T17:06:48Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0959-4965 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/93986 | - |
dc.description.abstract | Hyperphosphorylated tau is a main component of neurofibrillary tangles, a pathological hallmark of Alzheimer's disease (AD). There is evidence that various protein kinases are involved in tau hyperphosphorylation. However, little is known about AD-related stimuli that activates tau kinases. We investigated the role of zinc, a metal involved in AD pathology, in tau phosphorylation. Zinc increased the phosphorylation of serine 214 (S214) in tau protein in human wild-type tau1-441-expressing SH-SY5Y cells. The phosphorylation was inhibited by suppressing the Ras-Raf/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (ERK) pathway. Mutation of serine to alanine at residue 214 of tau reduced microtubule polymerization impairment by ERK phosphorylation. These data suggest that zinc induces S214 phosphorylation in tau through ERK activation and interferes with microtubule polymerization | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 839~844 | - |
dc.relation.isPartOf | NEUROREPORT | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Extracellular Signal-Regulated MAP Kinases/metabolism | - |
dc.subject.MESH | Extracellular Signal-Regulated MAP Kinases/physiology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | MAP Kinase Signaling System/physiology* | - |
dc.subject.MESH | Microtubules/metabolism | - |
dc.subject.MESH | Microtubules/pathology | - |
dc.subject.MESH | Phosphorylation/physiology | - |
dc.subject.MESH | Polymerization* | - |
dc.subject.MESH | Serine/metabolism* | - |
dc.subject.MESH | Zinc/physiology* | - |
dc.subject.MESH | raf Kinases/metabolism* | - |
dc.subject.MESH | raf Kinases/physiology | - |
dc.subject.MESH | ras Proteins/metabolism* | - |
dc.subject.MESH | ras Proteins/physiology | - |
dc.subject.MESH | tau Proteins/metabolism* | - |
dc.title | Zinc stimulates tau S214 phosphorylation by the activation of Raf/mitogen-activated protein kinase-kinase/extracellular signal-regulated kinase pathway | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pharmacology (약리학) | - |
dc.contributor.googleauthor | Insook Kim | - |
dc.contributor.googleauthor | Eun Ji Park | - |
dc.contributor.googleauthor | Jeho Seo | - |
dc.contributor.googleauthor | Suk Jin Ko | - |
dc.contributor.googleauthor | Jinu Lee | - |
dc.contributor.googleauthor | Chul Hoon Kim | - |
dc.identifier.doi | 10.1097/WNR.0b013e32834c0a2d | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01057 | - |
dc.relation.journalcode | J02361 | - |
dc.identifier.eissn | 1473-558X | - |
dc.identifier.pmid | 21934536 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00001756-201111160-00011&LSLINK=80&D=ovft | - |
dc.subject.keyword | Alzheimer’s disease | - |
dc.subject.keyword | extracellular signal-regulated kinase | - |
dc.subject.keyword | neurofibrillary tangle | - |
dc.subject.keyword | phosphorylation | - |
dc.subject.keyword | tau | - |
dc.subject.keyword | tau kinases | - |
dc.contributor.alternativeName | Kim, Chul Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Chul Hoon | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 22 | - |
dc.citation.number | 16 | - |
dc.citation.startPage | 839 | - |
dc.citation.endPage | 844 | - |
dc.identifier.bibliographicCitation | NEUROREPORT, Vol.22(16) : 839-844, 2011 | - |
dc.identifier.rimsid | 28596 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.