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줄기세포의 신경계 임상적용Ⅰ: 신경줄기세포를 중심으로

Other Titles
 Clinical applications of human neural stem cells in neurodegenerative diseases, especially neonatal hypoxic-ischemic brain injury and spinal cord injury 
Authors
 박국인 
Citation
 JOURNAL OF THE KOREAN MEDICAL ASSOCIATION, Vol.54(5) : 468-481, 2011 
Journal Title
JOURNAL OF THE KOREAN MEDICAL ASSOCIATION(대한의사협회지)
ISSN
 1975-8456 
Issue Date
2011
Keywords
Neural stem cells ; Hypoxic-ischemic brain injury ; Spinal cord injuries ; Cell therapy
Abstract
Multipotent neural stem cells (NSCs) are operationally defined by their ability to self-renew, to
differentiate into cells of all glial and neuronal lineages throughout the neuraxis, and to
populate developing or degenerating CNS regions. The recognition that NSCs that were propagated
in culture could be reimplanted into the mammalian brain, where they might integrate
appropriately throughout the mammalian CNS and stably express foreign genes, has unveiled a
new role for neural transplantation and gene therapy and a possible strategy for addressing the
CNS manifestations of diseases that heretofore had been refractory to intervention. Proliferating
single cells were isolated from the telencephalic region of human fetal cadavers at 13 weeks of
gestation and were grown as neurospheres in long-term cultures. We investigated the characteristics
of the growth, differentiation, and region-specific gene expression of human NSCs. An
intriguing phenomenon with possible therapeutic potentials has begun to emerge from our observations
of the behavior of NSCs in animal models of neonatal hypoxic-ischemic brain and spinal
cord injury. During phases of active neurodegeneration, factors seem to be transiently elaborated
to which NSCs may respond by migrating to degenerating regions and differentiating specifically
towards replacement of dying neural cells. NSCs may attempt to repopulate and reconstitute
ablated regions. In addition, NSCs may serve as vehicles for gene delivery and appear capable
of simultaneous neural cell replacement and gene therapy. After the approval of the Institutional
Review Board of Severance Hospital, Yonsei University College of Medicine and Korean Food
and Drug Administration, an investigator-sponsored clinical trial of the transplantation of human
NSCs into patients with severe perinatal hypoxic ischemic brain injury and traumatic cervical
motor complete spinal cord injury have been performed. The existing data from these clinical
trials have shown to be safe, well tolerated, and of neurologically-some benefits.
Files in This Item:
T201103117.pdf Download
DOI
10.5124/jkma.2011.54.5.468
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Park, Kook In(박국인) ORCID logo https://orcid.org/0000-0001-8499-9293
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93930
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