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Acute promyelocytic leukemia with complex translocation t(5;17;15)(q35;q21;q22): case report and review of the literature.

Authors
 Sung Ran Cho  ;  Seo-Jin Park  ;  Jun Eun Park  ;  Hyun Joo Jung  ;  Jong Rak Choi  ;  Il Joong Park  ;  Hyon J. Kim 
Citation
 Journal of Pediatric Hematology Oncology, Vol.33(7) : 326-9, 2011 
Journal Title
 Journal of Pediatric Hematology Oncology 
ISSN
 1077-4114 
Issue Date
2011
Abstract
The t(15;17)(q22;q21), resulting in PML-RARA fusion gene, is a characteristic chromosomal translocation in acute promyelocytic leukemia (APL). We report a pediatric APL case with a 3-way translocation: t(5;17;15)(q35;q21;q22). Complete blood cell counts of a 12-year-old girl, of pale appearance, showed pancytopenia with increased blasts. Morphology and immunophenotype of the leukemic cells were compatible with APL. Karyotype analysis showed t(5;17;15)(q35;q21;q22) and add(7)(q32). We detected the PML-RARA fusion gene by both reverse transcriptase-polymerase chain reaction and fluorescent in situ hybridization analysis. The patient underwent successful treatment with cytarabine with all-trans retinoic acid and anthracycline-based therapy.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93919
DOI
10.1097/MPH.0b013e31820998de
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실)
Yonsei Authors
최종락(Choi, Jong Rak)
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