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Peripheral compressing artifacts in brain tissue from stereotactic biopsy with sidecutting biopsy needle: a pitfall for adequate glioma grading.

Authors
 S.H. Kim  ;  W.S. Chang  ;  J.P. Kim  ;  Y.K. Minn  ;  J. Choi  ;  J.W. Chang  ;  T.S. Kim  ;  Y.G. Park  ;  J.H. Chang 
Citation
 Clinical Neuropathology, Vol.30(6) : 328-332, 2011 
Journal Title
 Clinical Neuropathology 
ISSN
 0722-5091 
Issue Date
2011
Abstract
Aims: The stereotactic brain biopsy is an essential diagnostic procedure in modern neurologic patient management. A side-cutting biopsy needle is one of the most widely used needle types. Recently we found a characteristic tissue artifact named "peripheral compressing artifact" in the brain tissues biopsied using a side-cutting needle of Leksell's system. We investigate prevalence, possible cause and its clinical implication of this type of artifact. Materials and methods: We examined the biopsies from 80 patients (44 cases of gliomas, 13 lymphomas, 7 germ cell tumors, 2 other tumors, 1 metastatic carcinoma, 4 non-tumorous conditions such as demyelinating disease and 8 non-diagnostic) in the stereotactic biopsy group with a suspected brain tumor, who underwent a stereotactic brain biopsy using side-cutting needle of Leksell's system. We also evaluated 16 cases of open brain biopsies without Leksell's system as a control group. Results: The artifact is a semi-circular or band-like tissue compression in the periphery of the biopsied tissue. This artifact was found in 30 (37.5%) out of 80 cases and 57 (11.9%) out of 477 biopsied pieces. It might be produced during rotating of the inner cannula of the biopsy needle. Histologically, it might be misinterpreted as "hypercellular", "spindle", "well circumscribed", or rarely as "pseudopalisading" especially in glioma. Conclusions: Awareness of this artifact would help making the appropriate pathological diagnosis for glioma.
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DOI
10.5414/NP300404
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Hoon(김세훈) ORCID logo https://orcid.org/0000-0001-7516-7372
Kim, Joo Pyung(김주평)
Kim, Tai Seung(김태승)
Park, Yong Gou(박용구)
Chang, Won Seok(장원석) ORCID logo https://orcid.org/0000-0003-3145-4016
Chang, Jong Hee(장종희)
Chang, Jin Woo(장진우) ORCID logo https://orcid.org/0000-0002-2717-0101
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93906
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