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Obstetric and perinatal outcomes of dichorionic twin pregnancies according to methods of conception: spontaneous versus in-vitro fertilization

 Hyoin Yang  ;  Young Sik Choi  ;  Ka Hyun Nama  ;  Ja Young Kwon  ;  Yong Won Park  ;  Young Han Kim 
 TWIN RESEARCH AND HUMAN GENETICS, Vol.14(1) : 98-103, 2011 
Journal Title
Issue Date
Adult ; Birth Weight* ; Female ; Fertilization ; Fertilization in Vitro/adverse effects* ; Fertilization in Vitro/statistics & numerical data* ; Gestational Age ; Humans ; Infant, Low Birth Weight ; Infant, Newborn ; Infant, Premature ; Logistic Models ; Maternal Age ; Multivariate Analysis ; Parturition ; Pregnancy ; Pregnancy Complications/etiology* ; Pregnancy Outcome* ; Pregnancy, Multiple ; Premature Birth/etiology* ; Retrospective Studies ; Twins, Dizygotic
We have observed the inconsistent findings from various studies on twin pregnancy outcomes obtained by assisted reproductive technology and spontaneous conception. In most studies, however, the concrete chorionicity, regarded as a confounding factor for predicting the perinatal outcomes of twin pregnancies, has not been determined. The purpose of this study was to compare obstetric and perinatal outcomes of only the dichorionic twin pregnancies according to the methods of conception: spontaneous and in-vitro fertilization (IVF). The twin pairs with dichorionicity reported from 1995 to 2008 were investigated and we divided them into two groups which consisted of 286 and 134 twins by spontaneous conception and IVF, respectively. Odds ratios for associations between IVF and pregnancy outcomes were analyzed after adjustment for maternal age and parity. There were no risk differences between the two groups regarding the obstetric complications, which include preterm delivery, preterm labor, preterm premature rupture of membranes, preeclampsia, placenta previa, and abruption. Any differences were not shown in the two groups for the risk estimates of perinatal outcomes, such as low birthweight, very low birthweight, small for gestational age, Apgar scores of < 7 at 5 minutes, discordance in birthweights, congenital anomalies and mortality. However, twins conceived after IVF were less likely to be admitted to the neonatal intensive care unit than those conceived spontaneously (adjusted OR 0.488; 95% confidence interval 0.261-0.910). In the cases of dichorionic twins, IVF may not be associated with adverse perinatal and obstetric outcomes compared with spontaneous conception
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1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Ja Young(권자영) ORCID logo https://orcid.org/0000-0003-3009-6325
Kim, Young Han(김영한) ORCID logo https://orcid.org/0000-0003-0645-6028
Nam, Ka Hyun(남가현)
Park, Yong Won(박용원)
Yang, Hyo In(양효인)
Choi, Young Sik(최영식) ORCID logo https://orcid.org/0000-0002-1157-4822
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