Cited 21 times in
Effects of hepatocyte growth factor on collagen synthesis and matrix metalloproteinase production in keloids
DC Field | Value | Language |
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dc.contributor.author | 나동균 | - |
dc.contributor.author | 박상은 | - |
dc.contributor.author | 이원재 | - |
dc.date.accessioned | 2014-12-20T17:03:39Z | - |
dc.date.available | 2014-12-20T17:03:39Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/93886 | - |
dc.description.abstract | Keloids are pathologic proliferations of the dermal layer of the skin resulting from excessive collagen production and deposition. Hepatocyte growth factor (HGF) increases the expression of matrix metalloproteinase (MMP)-1 and suppresses collagen synthesis to modulate extracellular matrix turnover. To investigate the anti-fibrotic effects of HGF, we examine the mRNA expression of collagen types I and III and matrix metalloproteinase (MMP-1, MMP-3) on human dermal fibroblast (HDF) cell lines and keloid fibroblasts (KFs, n = 5) after adding various amount of HGF protein. We also evaluated the enzymatic activity of MMP-2, MMP-9 by zymograghy. In HDFs treated with TGF-β1 and HGF protein simultaneously, both type I and III collagen mRNA expression significantly decreased (P < 0.05). Expression of MMP-1, MMP-3 mRNA also decreased. However, the mRNA expression of MMP-1, MMP-3 significantly increased in KFs with increasing amount of HGF in dose dependent manner (P < 0.05). The enzymatic activities of MMP-2 increased with increasing HGF protein in a dose-dependent manner. However, the enzymatic activity of MMP-9 did not change. These results suggest that the anti-fibrotic effects of HGF may have therapeutic effects on keloids by reversing pathologic fibrosis. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1081~1086 | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Collagen Type I/genetics | - |
dc.subject.MESH | Collagen Type I/metabolism | - |
dc.subject.MESH | Collagen Type III/genetics | - |
dc.subject.MESH | Collagen Type III/metabolism | - |
dc.subject.MESH | Fibroblasts/drug effects | - |
dc.subject.MESH | Fibroblasts/metabolism | - |
dc.subject.MESH | Hepatocyte Growth Factor/pharmacology* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Keloid/metabolism* | - |
dc.subject.MESH | Keloid/pathology | - |
dc.subject.MESH | Matrix Metalloproteinase 1/genetics | - |
dc.subject.MESH | Matrix Metalloproteinase 1/metabolism | - |
dc.subject.MESH | Matrix Metalloproteinase 2/metabolism | - |
dc.subject.MESH | Matrix Metalloproteinase 3/genetics | - |
dc.subject.MESH | Matrix Metalloproteinase 3/metabolism | - |
dc.subject.MESH | Matrix Metalloproteinase 9/metabolism | - |
dc.subject.MESH | RNA, Messenger/metabolism | - |
dc.subject.MESH | Transforming Growth Factor beta1/pharmacology | - |
dc.title | Effects of hepatocyte growth factor on collagen synthesis and matrix metalloproteinase production in keloids | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Plastic Surgery & Reconstructive Surgery (성형외과학) | - |
dc.contributor.googleauthor | Won Jai Lee | - |
dc.contributor.googleauthor | Sang Eun Park | - |
dc.contributor.googleauthor | Dong Kyun Rah | - |
dc.identifier.doi | 10.3346/jkms.2011.26.8.1081 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01229 | - |
dc.contributor.localId | A01488 | - |
dc.contributor.localId | A03005 | - |
dc.relation.journalcode | J01517 | - |
dc.identifier.eissn | 1598-6357 | - |
dc.identifier.pmid | 21860560 | - |
dc.subject.keyword | Collagen | - |
dc.subject.keyword | Dermal Fibroblast | - |
dc.subject.keyword | Hepatocyte Growth Factor | - |
dc.subject.keyword | Keloid Fibroblast | - |
dc.subject.keyword | Matrix Metalloproteinase | - |
dc.contributor.alternativeName | Rah, Dong Kyun | - |
dc.contributor.alternativeName | Park, Sang Eun | - |
dc.contributor.alternativeName | Lee, Won Jai | - |
dc.contributor.affiliatedAuthor | Rah, Dong Kyun | - |
dc.contributor.affiliatedAuthor | Park, Sang Eun | - |
dc.contributor.affiliatedAuthor | Lee, Won Jai | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 26 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1081 | - |
dc.citation.endPage | 1086 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.26(8) : 1081-1086, 2011 | - |
dc.identifier.rimsid | 28525 | - |
dc.type.rims | ART | - |
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