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Predictive clinical parameters for the therapeutic efficacy of sitagliptin in korean type 2 diabetes mellitus

Authors
 Soon Ae Kim  ;  Woo Ho Shim  ;  Eun Hae Lee  ;  Young Mi Lee  ;  Sun Hee Beom  ;  Eun Sook Kim  ;  Jeong Seon Yoo  ;  Ji Sun Nam  ;  Min Ho Cho  ;  Jong Suk Park  ;  Chul Woo Ahn  ;  Kyung Rae Kim 
Citation
 DIABETES & METABOLISM JOURNAL, Vol.35(2) : 159-165, 2011 
Journal Title
 DIABETES & METABOLISM JOURNAL 
ISSN
 2233-6079 
Issue Date
2011
Keywords
Diabetes mellitus, type 2 ; Dipeptidyl peptide-4 inhibitor ; Sitagliptin
Abstract
BACKGROUND: Sitagliptin is a highly selective dipeptidyl peptide-4 (DPP-4) inhibitor that increases blood levels of active glucagon-like peptide (GLP)-1 and glucose-dependent insulinotrophic polypeptide (GIP), resulting in increased insulin secretion. While studies conducted in other countries have indicated the efficacy and safety of using sitagliptin to treat type 2 diabetes mellitus (T2DM), its predictors of effects to sitagliptin are not well understood. Therefore, we evaluated the predictive clinical parameters for the therapeutic benefits of sitagliptin when added to an ongoing metformin or sulfonylurea therapy in Korean T2DM subjects. METHODS: We obtained data from 251 Korean T2DM subjects who had recently started taking sitagliptin as add-on therapy. Exclusion criteria included any insulin use. Changes in HbA1c (ΔHbA1c) and fasting plasma glucose (ΔFPG) were assessed by comparing baseline levels prior to sitagliptin administration to levels 12 and 24 weeks after treatment. Responders were defined as subjects who experienced decrease from baseline of >10% in ΔHbA1c or >20% in ΔFPG levels at 24 weeks. RESULTS: We classified 81% of the subjects (204 out of 251) as responders. The responder group had a lower mean body mass index (23.70±2.40 vs. 26.00±2.26, P≤0.01) and were younger (58.83±11.57 years vs. 62.87±12.09 years, P=0.03) than the non-responder group. CONCLUSION: In Korean T2DM subjects, sitagliptin responders had lower body mass index and were younger compared to non-responders.
Files in This Item:
T201103077.pdf Download
DOI
10.4093/dmj.2011.35.2.159
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Rae(김경래)
Kim, Soon Ae(김순애)
Kim, Eun Sook(김은숙)
Nam, Ji Sun(남지선) ORCID logo https://orcid.org/0000-0001-8655-5258
Park, Jong Suk(박종숙) ORCID logo https://orcid.org/0000-0002-5385-1373
Beom, Sun Hee(범선희)
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Yoo, Jeong Seon(유정선)
Lee, Eun Hae(이은해)
Cho, Min Ho(조민호)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93876
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