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Predictive clinical parameters for the therapeutic efficacy of sitagliptin in korean type 2 diabetes mellitus

 Soon Ae Kim  ;  Woo Ho Shim  ;  Eun Hae Lee  ;  Young Mi Lee  ;  Sun Hee Beom  ;  Eun Sook Kim  ;  Jeong Seon Yoo  ;  Ji Sun Nam  ;  Min Ho Cho  ;  Jong Suk Park  ;  Chul Woo Ahn  ;  Kyung Rae Kim 
 Diabetes & Metabolism Journal, Vol.35(2) : 159-165, 2011 
Journal Title
 Diabetes & Metabolism Journal 
Issue Date
BACKGROUND: Sitagliptin is a highly selective dipeptidyl peptide-4 (DPP-4) inhibitor that increases blood levels of active glucagon-like peptide (GLP)-1 and glucose-dependent insulinotrophic polypeptide (GIP), resulting in increased insulin secretion. While studies conducted in other countries have indicated the efficacy and safety of using sitagliptin to treat type 2 diabetes mellitus (T2DM), its predictors of effects to sitagliptin are not well understood. Therefore, we evaluated the predictive clinical parameters for the therapeutic benefits of sitagliptin when added to an ongoing metformin or sulfonylurea therapy in Korean T2DM subjects. METHODS: We obtained data from 251 Korean T2DM subjects who had recently started taking sitagliptin as add-on therapy. Exclusion criteria included any insulin use. Changes in HbA1c (ΔHbA1c) and fasting plasma glucose (ΔFPG) were assessed by comparing baseline levels prior to sitagliptin administration to levels 12 and 24 weeks after treatment. Responders were defined as subjects who experienced decrease from baseline of >10% in ΔHbA1c or >20% in ΔFPG levels at 24 weeks. RESULTS: We classified 81% of the subjects (204 out of 251) as responders. The responder group had a lower mean body mass index (23.70±2.40 vs. 26.00±2.26, P≤0.01) and were younger (58.83±11.57 years vs. 62.87±12.09 years, P=0.03) than the non-responder group. CONCLUSION: In Korean T2DM subjects, sitagliptin responders had lower body mass index and were younger compared to non-responders.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김경래(Kim, Kyung Rae)
김순애(Kim, Soon Ae)
김은숙(Kim, Eun Sook)
남지선(Nam, Ji Sun) ORCID logo https://orcid.org/0000-0001-8655-5258
박종숙(Park, Jong Suk) ORCID logo https://orcid.org/0000-0002-5385-1373
범선희(Beom, Sun Hee)
안철우(Ahn, Chul Woo)
유정선(Yoo, Jeong Seon)
이은해(Lee, Eun Hae)
조민호(Cho, Min Ho)
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