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Central aortic stiffness and its association with ascending aorta dilation in subjects with a bicuspid aortic valve

Authors
 Chi Young Shim  ;  In Jeong Cho  ;  Woo-In Yang  ;  Min-Kyung Kang  ;  Sungha Park  ;  Jong-Won Ha  ;  Yangsoo Jang  ;  Namsik Chung 
Citation
 JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY, Vol.24(8) : 847-852, 2011 
Journal Title
 JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY 
ISSN
 0894-7317 
Issue Date
2011
MeSH
Adult ; Aged ; Algorithms ; Aorta/diagnostic imaging* ; Aorta/physiopathology ; Aortic Diseases/diagnostic imaging* ; Aortic Diseases/pathology ; Aortic Diseases/physiopathology ; Aortic Valve/abnormalities* ; Aortic Valve/diagnostic imaging* ; Aortic Valve/physiopathology ; Case-Control Studies ; Dilatation, Pathologic/diagnostic imaging ; Early Diagnosis ; Echocardiography* ; Female ; Hemodynamics ; Humans ; Male ; Middle Aged ; Prospective Studies ; Risk Assessment ; Vascular Stiffness*
Abstract
BACKGROUND: Reduced elasticity and dilatation of the proximal aorta are highly prevalent in patients with bicuspid aortic valves (BAVs), even in the absence of valvular dysfunction. The aim of this study was to examine central aortic stiffness and its association with ascending aortic dilation in subjects with BAVs compared with controls. METHODS: Fifty subjects with BAVs (39 men; mean age, 52 ± 14 years) without significant valve dysfunction and 50 age-matched and gender-matched controls with normal trileaflet aortic valves were studied. Aortic diameter was measured using two-dimensional echocardiography, and central hemodynamics were assessed simultaneously using radial artery tonometry. Subjects with BAVs were divided into two groups on the basis of the median value of the aortic diameter. RESULTS: Subjects with BAVs had larger ascending aortic diameters (20.6 ± 4.0 vs 17.9 ± 2.4 mm/m(2), P < .001), higher augmentation indexes normalized for a heart rate of 75 beats/min (25.3 ± 9.7% vs 16.7 ± 8.6%, P < .001), higher pulse-wave velocities (7.8 ± 1.5 vs 7.2 ± 1.0 m/sec, P = .013), and lower pulse pressure amplification (1.24 ± 0.27 vs 1.35 ± 0.18, P = .022) than control subjects. The higher augmentation indexes were significant even in subjects with BAVs with relatively normal sized aortas. The diameter of the ascending aorta was correlated with augmentation index (r = 0.48, P < .001), pulse-wave velocity (r = 0.27, P = .063), and pulse pressure amplification (r = -0.46, P = .001) in subjects with BAVs. CONCLUSION: Subjects with BAVs had stiffer central hemodynamics than controls with tricuspid aortic valves, even in the absence of significant aortic dilation. Central aortic stiffness was positively correlated with the degree of aortic dilation in subjects with BAV. Thus, the evaluation of central aortic stiffness could be useful for the early detection and risk stratification of aortopathy in subjects with BAVs.
Full Text
http://www.sciencedirect.com/science/article/pii/S0894731711003269
DOI
10.1016/j.echo.2011.04.017
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Min Kyung(강민경)
Park, Sung Ha(박성하) ORCID logo https://orcid.org/0000-0001-5362-478X
Shim, Chi Young(심지영) ORCID logo https://orcid.org/0000-0002-6136-0136
Yang, Woo In(양우인)
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Chung, Nam Sik(정남식)
Cho, In Jeong(조인정)
Ha, Jong Won(하종원) ORCID logo https://orcid.org/0000-0002-8260-2958
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93823
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