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Overweight and its association with aortic pressure wave reflection after exercise

Authors
 Chi Young Shim  ;  Woo-In Yang  ;  Jong-Won Ha  ;  Namsik Chung  ;  Yangsoo Jang  ;  Donghoon Choi  ;  Young-Guk Ko  ;  Min-Kyung Kang  ;  Sungha Park 
Citation
 American Journal of Hypertension, Vol.24(10) : 1136-1142, 2011 
Journal Title
 American Journal of Hypertension 
ISSN
 0895-7061 
Issue Date
2011
Abstract
BACKGROUND: Obesity is associated with arterial stiffening, left ventricular (LV) hypertrophy, and diastolic dysfunction. However, there is no data regarding dynamic changes in arterial hemodynamics with exercise in overweight subjects. We hypothesized that overweight women would show a different exercise response in wave reflection compared with lean women. METHODS: A total of 59 overweight and 68 lean nondiabetic women (mean age 63 ± 7 years) underwent symptom-limited supine bicycle exercise testing with simultaneous two-dimensional and Doppler echocardiography. Central hemodynamics including central aortic pressure and augmentation index (AIx) were obtained at rest and immediately after peak exercise using radial artery tonometry. RESULTS: Overweight women showed a higher LV mass index (lean vs. overweight; 40.2 ± 10.2 vs. 45.3 ± 11.0 g/m(2.7), P = 0.007) and a lower early diastolic mitral annular velocity (6.3 ± 1.8 vs. 5.5 ± 1.6 cm/s, P = 0.013) than lean women. Although the two groups did not differ in peripheral and central hemodynamics including AIx (36.3 ± 11.7 vs. 36.8 ± 10.2%, P = 0.830) and AIx normalized for heart rate 75/min (AIx@75, 30.4 ± 11.5 vs. 30.1 ± 9.9%, P = 0.885) at rest, AIx (20.9 ± 11.5 vs. 27.6 ± 10.4%, P = 0.004) and AIx@75 (25.8 ± 10.2 vs. 31.6 ± 7.7%, P = 0.002) at peak exercise were significantly higher in overweight women. In simple correlation analysis, body mass index (BMI) showed significant correlations with AIx, and AIx@75 at peak exercise, whereas no relationships were found with those parameters at rest. Multiple regression analysis showed that BMI was an independent determinant of AIx@75 at peak exercise (β = 0.28, P = 0.004). CONCLUSIONS: Despite similar resting peripheral and central hemodynamics, the wave reflection in overweight women after exercise differed from that in lean women. These findings suggest that being overweight is related to higher wave reflection after exercise.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93820
DOI
10.1038/ajh.2011.121
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
강민경(Kang, Min Kyung) ; 고영국(Ko, Young Guk) ; 박성하(Park, Sung Ha) ; 심지영(Shim, Chi Young) ; 양우인(Yang, Woo In) ; 장양수(Jang, Yang Soo) ; 정남식(Chung, Nam Sik) ; 최동훈(Choi, Dong Hoon) ; 하종원(Ha, Jong Won)
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Full Text
http://ajh.oxfordjournals.org/content/24/10/1136.long
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