4 598

Cited 154 times in

Impact of contrast-induced acute kidney injury with transient or persistent renal dysfunction on long-term outcomes of patients with acute myocardial infarction undergoing percutaneous coronary intervention

 Jin Wi  ;  Young-Guk Ko  ;  Jung-Sun Kim  ;  Byeong-Keuk Kim  ;  Donghoon Choi  ;  Jong-Won Ha  ;  Myeong-Ki Hong  ;  Yangsoo Jang 
 HEART, Vol.97(21) : 1753-1757, 2011 
Journal Title
Issue Date
Acute Kidney Injury/chemically induced* ; Adult ; Aged ; Angioplasty, Balloon, Coronary/adverse effects* ; Angioplasty, Balloon, Coronary/methods ; Contrast Media/adverse effects* ; Disease Progression ; Epidemiologic Methods ; Female ; Humans ; Iohexol/adverse effects ; Iohexol/analogs & derivatives ; Kidney Failure, Chronic/chemically induced ; Kidney Failure, Chronic/therapy ; Male ; Middle Aged ; Myocardial Infarction/therapy* ; Prognosis ; Renal Dialysis ; Triiodobenzoic Acids/adverse effects ; Young Adult
OBJECTIVE: To investigate the long-term prognostic implications of contrast-induced acute kidney injury (CI-AKI) with transient or persistent renal dysfunction in acute myocardial infarction (AMI) patients undergoing percutaneous coronary intervention (PCI).

DESIGN: A retrospective observational registry study.

SETTING: Clinical follow-up after PCI. Patients and methods A total of 1041 PCI-treated AMI patients from the Infarction Prognosis Study registry. CI-AKI was defined as an increase in serum creatinine (>25% or >0.5 mg/dl (>44.2 μmol/l)) within 2 days after PCI. Main outcome measures Two-year cumulative event rate of all-cause death or renal failure requiring dialysis.

RESULTS: CI-AKI was observed in 148 patients (14.2%). Patients with CI-AKI had a higher rate of death or dialysis (25.4% vs. 6.3%, p<0.001) at 2 years compared with patients without CI-AKI. CI-AKI was an important independent predictor of death or dialysis (HR 2.76, 95% CI 1.61 to 4.73, p<0.001) Persistent renal dysfunction after CI-AKI was documented in 68 patients (45.9%). Patients with transient renal dysfunction showed a lower 2-year event rate of death or dialysis compared with those with persistent renal dysfunction (17.9% vs. 34.1%, p=0.013); however, they showed a higher event rate compared with those without CI-AKI (17.9% vs. 6.3%, p<0.001).

CONCLUSION: Transient and persistent renal dysfunction after CI-AKI was associated with increased short and long-term mortality and morbidity in AMI patients treated by PCI. Better preventive strategies are needed to improve clinical outcomes in AMI patients at high risk of developing CI-AKI
Full Text
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ko, Young Guk(고영국) ORCID logo https://orcid.org/0000-0001-7748-5788
Kim, Byeong Keuk(김병극) ORCID logo https://orcid.org/0000-0003-2493-066X
Kim, Jung Sun(김중선) ORCID logo https://orcid.org/0000-0003-2263-3274
Wi, Jin(위진) ORCID logo https://orcid.org/0000-0003-0655-5130
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Choi, Dong Hoon(최동훈) ORCID logo https://orcid.org/0000-0002-2009-9760
Ha, Jong Won(하종원) ORCID logo https://orcid.org/0000-0002-8260-2958
Hong, Myeong Ki(홍명기) ORCID logo https://orcid.org/0000-0002-2090-2031
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.