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호산구 식도염의 임상병리학적 특징 분석: 비폐쇄성 연하곤란과의 비교 연구

Other Titles
 Analysis of the Clinicopathologic Features of Eosinophilic Esophagitis: Comparative Study with Nonobstructive Dysphagia 
 김광현  ;  정일형  ;  김지현  ;  윤영훈  ;  윤선옥  ;  박효진  ;  이상인 
 Korean Journal of Gastrointestinal Endoscopy (대한소화기내시경학회지), Vol.42(3) : 143-151, 2011 
Journal Title
 Korean Journal of Gastrointestinal Endoscopy  (대한소화기내시경학회지) 
Issue Date
Background/Aims: Eosinophilic esophagitis (EoE) has emerged as one of the most common causes of dysphagia and esophageal food impactions. However, it is doubtful that gastroenterologists and pathologists make the correct diagnosis of EoE because of the insufficient recognition of EoE based on the endoscopic and pathological findings. This study was performed to investigate the symptoms and the endoscopic and pathologic findings of EoE as compared with those of nonobstructive dysphagia (NOD). Methods: We retrospectively reviewed the medical records and the endoscopic and pathologic findings from 12 patients who were diagnosed with EoE based on an eosinophil count of ≥20 per high-power field (HPF) and 13 patients diagnosed with NOD, and these patients were treated at our hospital from June 2006 till October 2010. Results: The endoscopic findings of EoE included rings (41.7%), furrows (75.0%), exudates (33.3%), mucosal friability (8.3%) and multi-findings (6.7%). Furrows and multi-findings were identified more frequently in EoE as comparison to that in NOD. The pathologic findings revealed that the maximal eosinophil counts/HPF were 87.2 (range 20∼232) and 2.2 (0∼11) in EoE and NOD, respectively. Moreover, eosinophil microabscess (58.3%), degranulation (100%) and spongiosis (91.7%) were more significantly observed in EoE compared with that in NOD. Conclusions: EoE had specific endoscopic and clinicopathologic features that distinguish it from NOD. For patients with dysphagia, the endoscopic and pathologic findings of EoE should be kept in mind
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김광현(Kim, Kwang Hyun) ; 김지현(Kim, Jie-Hyun) ; 박효진(Park, Hyo Jin) ; 윤선옥(Yoon, Sun Och) ; 윤영훈(Youn, Young Hoon) ; 이상인(Lee, Sang In) ; 정일형(Chung, Il Hyung)
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