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Subthreshold continuous electrical stimulation facilitates functional recovery of facial nerve after crush injury in rabbit

Authors
 Jin Kim ; Su Jin Han ; Jae Young Choi ; Won-sang Lee ; Dong Hyun Shin 
Citation
 Muscle & Nerve, Vol.43(2) : 251~258, 2011 
Journal Title
 Muscle & Nerve 
ISSN
 0148-639X 
Issue Date
2011
Abstract
We sought to determine whether electrical stimulation (ES) with subthreshold, continuous, low-frequency impulses is a viable clinical method for improving functional recovery after facial nerve crush injury. In 10 rabbits, bilateral crush injuries were made on the facial nerve by compression for 30 s with mosquito forceps, causing complete facial paralysis. Subthreshold continuous direct current ES with 20-Hz square-wave pulses was applied to the proximal stump on one side for 4 weeks. Vibrissae movement returned significantly earlier on the ES side, with a less variable recovery time. Electrophysiologically, the stimulated side had a significantly shorter latency, longer duration, and faster conduction velocity. Light and transmission electron microscopy revealed that the electrical stimulation also markedly decreased Wallerian degeneration. The average numbers of fluorescent, double-labeled nerve cells were significantly different between the ES and non-ES sides. This study shows that subthreshold, continuous, low-frequency ES immediately after a crush injury of the facial nerve results in earlier recovery of facial function and shorter overall recovery time
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/93608
DOI
10.1002/mus.21840
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Otorhinolaryngology
Yonsei Authors
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Link
 http://onlinelibrary.wiley.com/doi/10.1002/mus.21840/abstract
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