Cited 53 times in
Self-assembled and nanostructured siRNA delivery systems
DC Field | Value | Language |
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dc.contributor.author | 김선화 | - |
dc.date.accessioned | 2014-12-20T16:53:49Z | - |
dc.date.available | 2014-12-20T16:53:49Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0724-8741 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/93584 | - |
dc.description.abstract | A wide range of organic and inorganic materials have been used in the development of nano-scale self-assembling gene delivery systems to improve the therapeutic efficacy of nucleic acid drugs. Small interfering RNA (siRNA) has recently been recognized as a promising and potent nucleic acid medicine for the treatment of incurable genetic disorders including cancer; however, siRNA-based therapeutics suffer from the same delivery problems as conventional nucleic acid drugs such as plasmid DNA and antisense oligonucleotides. Many of the delivery strategies developed for nucleic acid drugs have been applied to siRNA therapeutics, but they have not produced satisfactory in vivo gene silencing efficiencies to warrant clinical trials. This review discusses recent progress in the development of self-assembled and nanostructured delivery systems for efficient siRNA-induced gene silencing and their potential application in clinical settings. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 2072~2085 | - |
dc.relation.isPartOf | PHARMACEUTICAL RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cations | - |
dc.subject.MESH | Drug Carriers/chemistry* | - |
dc.subject.MESH | Drug Stability | - |
dc.subject.MESH | Gene Silencing/drug effects | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lipids/chemistry | - |
dc.subject.MESH | Nanoparticles/chemistry* | - |
dc.subject.MESH | Oligonucleotides, Antisense/administration & dosage | - |
dc.subject.MESH | Particle Size | - |
dc.subject.MESH | Peptides/chemistry | - |
dc.subject.MESH | Plasmids/administration & dosage | - |
dc.subject.MESH | Polyethylene Glycols/chemistry | - |
dc.subject.MESH | RNA, Small Interfering/administration & dosage* | - |
dc.subject.MESH | RNA, Small Interfering/pharmacology | - |
dc.title | Self-assembled and nanostructured siRNA delivery systems | - |
dc.type | Article | - |
dc.contributor.college | Researcher Institutes (부설 연구소) | - |
dc.contributor.department | Yonsei Integrative Research Institute for Cerebral & Cardiovascular Disease (뇌심혈관질환융합연구사업단) | - |
dc.contributor.googleauthor | Ji Hoon Jeong | - |
dc.contributor.googleauthor | Tae Gwan Park | - |
dc.contributor.googleauthor | Sun Hwa Kim | - |
dc.identifier.doi | 10.1007/s11095-011-0412-y | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00561 | - |
dc.relation.journalcode | J02503 | - |
dc.identifier.eissn | 1573-904X | - |
dc.identifier.pmid | 21424157 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs11095-011-0412-y | - |
dc.subject.keyword | non-viral gene carriers | - |
dc.subject.keyword | PEGylated polyplex | - |
dc.subject.keyword | self-assembled nanostructures | - |
dc.subject.keyword | siRNA medicines | - |
dc.subject.keyword | siRNA-PEG conjugates | - |
dc.contributor.alternativeName | Kim, Sun Hwa | - |
dc.contributor.affiliatedAuthor | Kim, Sun Hwa | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 28 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 2072 | - |
dc.citation.endPage | 2085 | - |
dc.identifier.bibliographicCitation | PHARMACEUTICAL RESEARCH, Vol.28(9) : 2072-2085, 2011 | - |
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