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Relationships between genetic polymorphisms of triggering receptor expressed on myeloid cells-1 and inflammatory bowel diseases in the Korean population

DC FieldValueLanguage
dc.contributor.author김승원-
dc.contributor.author김원호-
dc.contributor.author김은수-
dc.contributor.author김태일-
dc.contributor.author문창모-
dc.contributor.author이현정-
dc.contributor.author천재희-
dc.contributor.author홍성필-
dc.date.accessioned2014-12-20T16:53:43Z-
dc.date.available2014-12-20T16:53:43Z-
dc.date.issued2011-
dc.identifier.issn0024-3205-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/93581-
dc.description.abstractAIMS: Triggering receptor expressed on myeloid cells-1 (TREM-1) has been shown to play a crucial role in the propagation of inflammatory responses. Recent studies have reported that TREM-1 expression is up-regulated in patients with inflammatory bowel disease (IBD). Therefore, we investigated the associations between TREM-1 genetic polymorphisms and IBD development and its phenotypes in the Korean population. MAIN METHODS: Three TREM-1 single nucleotide polymorphisms (SNPs, rs2234237, rs3789205, and rs9471535) were genotyped by Taqman technology on 202 Crohn's disease (CD), 265 ulcerative colitis (UC), 138 with intestinal Behcet's disease (BD), and 234 healthy controls and the relationships between these SNPs and IBD development and phenotypes were evaluated. KEY FINDINGS: We found that TREM-1 SNPs are significantly associated with the development of intestinal Behcet's disease (rs9471535: odds ratio [OR]=1.637, P=0.025; rs3789205: OR=1.668, P=0.019; rs2234237: OR=1.691, P=0.016), and in particular with skin involvement (rs9471535: OR=2.723, P=0.009; rs3789205: OR=2.477, P=0.017; rs2234237: OR=2.278, P=0.030) and the risk of azathioprine use (rs9471535: OR=2.722, P=0.021; rs3789205: OR=2.493, P=0.032; rs2234237: OR=2.638, P=0.026). However, TREM-1 SNPs were not significantly associated with the development of Crohn's disease or ulcerative colitis. SIGNIFICANCE: The results of our study suggest that TREM-1 SNPs may play a significant role in the development of intestinal Behcet's disease and may have modest effects on disease severity.-
dc.description.statementOfResponsibilityopen-
dc.format.extent289~294-
dc.relation.isPartOfLife Sciences-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleRelationships between genetic polymorphisms of triggering receptor expressed on myeloid cells-1 and inflammatory bowel diseases in the Korean population-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentYonsei Biomedical Research Center (연세의생명연구원)-
dc.contributor.googleauthorEun Suk Jung-
dc.contributor.googleauthorSeung Won Kim-
dc.contributor.googleauthorChang Mo Moon-
dc.contributor.googleauthorDong-Jik Shin-
dc.contributor.googleauthorNak-Hoon Son-
dc.contributor.googleauthorEun Soo Kim-
dc.contributor.googleauthorHyun Jung Lee-
dc.contributor.googleauthorSung Pil Hong-
dc.contributor.googleauthorTae Il Kim-
dc.contributor.googleauthorWon Ho Kim-
dc.contributor.googleauthorJae Hee Cheon-
dc.identifier.doi10.1016/j.lfs.2011.06.018-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00774-
dc.contributor.localIdA01079-
dc.contributor.localIdA01390-
dc.contributor.localIdA04404-
dc.contributor.localIdA00804-
dc.contributor.localIdA00656-
dc.contributor.localIdA03295-
dc.contributor.localIdA04030-
dc.relation.journalcodeJ02167-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0024320511003109-
dc.contributor.alternativeNameKim, Seung Won-
dc.contributor.alternativeNameKim, Won Ho-
dc.contributor.alternativeNameKim, Eun Soo-
dc.contributor.alternativeNameKim, Tae Il-
dc.contributor.alternativeNameMoon, Chang Mo-
dc.contributor.alternativeNameLee, Hyun Jung-
dc.contributor.alternativeNameCheon, Jae Hee-
dc.contributor.alternativeNameHong, Sung Pil-
dc.contributor.affiliatedAuthorKim, Won Ho-
dc.contributor.affiliatedAuthorKim, Tae Il-
dc.contributor.affiliatedAuthorMoon, Chang Mo-
dc.contributor.affiliatedAuthorHong, Sung Pil-
dc.contributor.affiliatedAuthorKim, Eun Soo-
dc.contributor.affiliatedAuthorKim, Seung Won-
dc.contributor.affiliatedAuthorLee, Hyun Jung-
dc.contributor.affiliatedAuthorCheon, Jae Hee-
dc.rights.accessRightsnot free-
dc.citation.volume89-
dc.citation.number9-10-
dc.citation.startPage289-
dc.citation.endPage294-
dc.identifier.bibliographicCitationLife Sciences, Vol.89(9-10) : 289-294, 2011-
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)

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