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Serotonin-related gene pathways associated with undifferentiated somatoform disorder

 Kyung Bong Koh  ;  Eun Hee Choi  ;  Young-joon Lee  ;  Mooyoung Han 
 PSYCHIATRY RESEARCH-NEUROIMAGING, Vol.189(2) : 246-250, 2011 
Journal Title
Issue Date
Adult ; Female ; Gene Frequency ; Genetic Predisposition to Disease* ; Genotype ; Humans ; Male ; Middle Aged ; Polymorphism, Single Nucleotide/genetics* ; Psychological Tests ; Receptors, Serotonin/genetics ; Serotonin/genetics* ; Serotonin Plasma Membrane Transport Proteins/genetics ; Signal Transduction/genetics* ; Somatoform Disorders/genetics* ; Somatoform Disorders/pathology ; Tryptophan Hydroxylase/classification ; Tryptophan Hydroxylase/genetics ; Young Adult
Undifferentiated somatoform disorder ; Specific serotonin-related gene pathways ; Epigenetic factors
It has been suggested that serotonergic hypofunction and serotonergic pathway genes underlie the somatic symptoms of somatoform disorders. We examined a variety of serotonin-related gene polymorphisms to determine whether undifferentiated somatoform disorder is associated with specific serotonin-related gene pathways. Serotonin-related polymorphic markers were assessed using single nucleotide polymorphism (SNP) genotyping. One hundred and two patients with undifferentiated somatoform disorder and 133 healthy subjects were enrolled. The genotype and allele frequencies of tryptophan hydroxylase (TPH)1 A218C, TPH2 rs1386494, serotonin receptor 2A-T102C (5-HTR 2A-T102C), 5-HTR 2A-G1438A and serotonin transporter (5HTTLPR) gene were compared between the groups. The Hamilton Rating Scale for Depression and the somatization subscale of the Symptom Checklist-90-Revised (SCL-90-R) were used for psychological assessment. Patients with undifferentiated somatoform disorder had higher frequencies of the TPH1 C allele than healthy controls (p=0.02) but the difference was not significant after Bonferroni correction. The frequency of TPH1 genotype also did not differ significantly between the patients and the healthy controls, nor did TPH2 rs1386494, 5-HTR 2A-T102C, 5-HTR 2A-G1438A or 5HTTLPR allele and genotype frequencies differ significantly between the two groups. These findings suggest that a variety of serotonin-related gene pathways are unlikely to be definite genetic risk factors for undifferentiated somatoform disorder. Therefore, the pathogenesis of the disorder may be related to epigenetic factors, including psychosocial and cultural factors. Nonetheless, future studies need to include a larger sample of subjects and polymorphisms of more serotonin-related gene variants.
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1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers
Yonsei Authors
Koh, Kyung Bong(고경봉)
Lee, Youngjoon(이영준) ORCID logo https://orcid.org/0000-0002-9602-5186
Choi, Eun Hee(최은희)
Han, Moo Young(한무영)
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