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Wnt5a plays a crucial role in determining tooth size during murine tooth development

DC FieldValueLanguage
dc.contributor.author신정오-
dc.contributor.author정한성-
dc.contributor.author조성원-
dc.date.accessioned2014-12-20T16:52:22Z-
dc.date.available2014-12-20T16:52:22Z-
dc.date.issued2011-
dc.identifier.issn0302-766X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/93539-
dc.description.abstractWe have previously demonstrated that tooth size is determined by dental mesenchymal factors. Exogenous bone morphogenetic protein (BMP)4, Noggin, fibroblast growth factor (FGF)3 and FGF10 have no effect on tooth size, despite the expressions of Bmp2, Bmp4, Fgf3, Fgf10 and Lef1 in the dental mesenchyme. Among the wingless (Wnt) genes that are differentially expressed during tooth development, only Wnt5a is expressed in the dental mesenchyme. The aims of the present study were to clarify the expression pattern of Wnt5a in developing tooth germs and the role of Wnt5a in the regulation of tooth size by treatment with exogenous WNT5A with/without an apoptosis inhibitor on in vitro tooth germs combined with transplantation into kidney capsules. Wnt5a was intensely expressed in both the dental epithelium and mesenchyme during embryonic days 14-17, overlapping partly with the expressions of both Shh and Bmp4. Moreover, WNT5A retarded the development of tooth germs by markedly inducing cell death in the non-dental epithelium and mesenchyme but not widely in the dental region, where the epithelial-mesenchymal gene interactions among Wnt5a, Fgf10, Bmp4 and Shh might partly rescue the cells from death in the WNT5A-treated tooth germ. Together, these results indicate that WNT5A-induced cell death inhibited the overall development of the tooth germ, resulting in smaller teeth with blunter cusps after tooth-germ transplantation. Thus, it is suggested that Wnt5a is involved in regulating cell death in non-dental regions, while in the dental region it acts as a regulator of other genes that rescue tooth germs from cell death.-
dc.description.statementOfResponsibilityopen-
dc.format.extent367~377-
dc.relation.isPartOfCell and Tissue Research-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAmino Acid Chloromethyl Ketones/pharmacology-
dc.subject.MESHAnimals-
dc.subject.MESHApoptosis/drug effects-
dc.subject.MESHBiological Assay-
dc.subject.MESHBody Patterning/drug effects-
dc.subject.MESHBone Morphogenetic Protein 4/genetics-
dc.subject.MESHBone Morphogenetic Protein 4/metabolism-
dc.subject.MESHBuffers-
dc.subject.MESHFibroblast Growth Factor 10/genetics-
dc.subject.MESHFibroblast Growth Factor 10/metabolism-
dc.subject.MESHGene Expression Regulation, Developmental/drug effects-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred ICR-
dc.subject.MESHModels, Biological-
dc.subject.MESHOrgan Size/drug effects-
dc.subject.MESHTooth/anatomy & histology*-
dc.subject.MESHTooth/cytology-
dc.subject.MESHTooth/drug effects-
dc.subject.MESHTooth/embryology*-
dc.subject.MESHTooth Germ/cytology-
dc.subject.MESHTooth Germ/drug effects-
dc.subject.MESHTooth Germ/embryology-
dc.subject.MESHTooth Germ/metabolism-
dc.subject.MESHWnt Proteins/genetics-
dc.subject.MESHWnt Proteins/metabolism*-
dc.subject.MESHWnt Proteins/pharmacology-
dc.subject.MESHWnt-5a Protein-
dc.titleWnt5a plays a crucial role in determining tooth size during murine tooth development-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Oral Biology (구강생물학)-
dc.contributor.googleauthorJinglei Cai-
dc.contributor.googleauthorNoriko Mutoh-
dc.contributor.googleauthorJeong-Oh Shin-
dc.contributor.googleauthorNobuyuki Tani-Ishii-
dc.contributor.googleauthorHayato Ohshima-
dc.contributor.googleauthorSung-Won Cho-
dc.contributor.googleauthorHan-Sung Jung-
dc.identifier.doi10.1007/s00441-011-1224-4-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03758-
dc.contributor.localIdA03837-
dc.contributor.localIdA02147-
dc.relation.journalcodeJ00474-
dc.identifier.pmid21879290-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs00441-011-1224-4-
dc.subject.keywordApoptosis-
dc.subject.keywordGene expression regulation-
dc.subject.keywordTooth transplantation-
dc.subject.keywordWnt proteins-
dc.subject.keywordMice (ICR)-
dc.contributor.alternativeNameShin, Jeong Oh-
dc.contributor.alternativeNameJung, Han Sung-
dc.contributor.alternativeNameCho, Sung Won-
dc.contributor.affiliatedAuthorJung, Han Sung-
dc.contributor.affiliatedAuthorCho, Sung Won-
dc.contributor.affiliatedAuthorShin, Jeong Oh-
dc.rights.accessRightsnot free-
dc.citation.volume345-
dc.citation.number3-
dc.citation.startPage367-
dc.citation.endPage377-
dc.identifier.bibliographicCitationCell and Tissue Research, Vol.345(3) : 367-377, 2011-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers

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