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Association of a polymorphism of BTN2A1 with dyslipidemia in East Asian populations

Authors
 TETSUO FUJIMAKI  ;  KIMIHIKO KATO  ;  YOSHIJI YAMADA  ;  YANGSOO JANG  ;  JONG HO LEE  ;  DONG-JIK SHIN  ;  YOSHINORI NOZAWA  ;  SHOJI SHINKAI  ;  HIROTO YOSHIDA  ;  MASASHI TANAKA  ;  YUKITOSHI AOYAGI  ;  KEI SATOH  ;  SACHIRO WATANABE  ;  KIYOSHI YOKOI  ;  HIDEKI HORIBE  ;  TETSURO YOHIDA  ;  MITSUTOSHI OGURI 
Citation
 Experimental and Therapeutic Medicine, Vol.2(4) : 745-749, 2011 
Journal Title
 Experimental and Therapeutic Medicine 
ISSN
 1792-0981 
Issue Date
2011
Abstract
We previously identified rs6929846 of the butyrophilin, subfamily 2, member A1 gene (BTN2A1) as a susceptibility locus for myocardial infarction in Japanese individuals by a genome-wide association study. The aim of the present study was to examine the relation of the rs6929846 polymorphism of BTN2A1 to dyslipidemia in Japanese and Korean populations, given that dyslipidemia is an important risk factor for myocardial infarction. A total of 10,953 individuals from three independent subject panels were examined. The relations of the rs6929846 polymorphism of BTN2A1 to serum concentrations of triglycerides, high-density lipoprotein (HDL)-cholesterol and low-density lipoprotein (LDL)-cholesterol were examined in each subject panel. The C→T polymorphism (rs6929846) of BTN2A1 was significantly associated with serum concentrations of triglycerides in Japanese subject panels A (P=0.0004) and B (P=0.0010), and in the Korean population (P=0.0095), with the minor T allele being related to an increased serum concentration of triglycerides. The rs6929846 was associated with serum concentrations of HDL-cholesterol in Japanese subject panels A (P=0.0047) and B (P=0.0015), with the T allele being related to a decreased serum concentration of HDL-cholesterol, but not in the Korean population. This polymorphism was associated with the serum concentration of LDL-cholesterol only in Japanese subject panel B (P=0.0059), with the T allele being related to an increased serum concentration of LDL-cholesterol. The results suggest that BTN2A1 may be a susceptibility gene for hypertriglyceridemia in East Asian populations and for low serum HDL-cholesterol in the Japanese population.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93425
DOI
10.3892/etm.2011.266
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
장양수(Jang, Yang Soo)
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