Cited 12 times in
Cytogenetics and prognosis for uveal melanoma in Korean patients
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 양우익 | - |
dc.contributor.author | 윤진숙 | - |
dc.contributor.author | 이상열 | - |
dc.contributor.author | 이성철 | - |
dc.contributor.author | 이승규 | - |
dc.contributor.author | 이준원 | - |
dc.date.accessioned | 2014-12-20T16:48:03Z | - |
dc.date.available | 2014-12-20T16:48:03Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1755-375X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/93402 | - |
dc.description.abstract | PURPOSE: To determine the rate of mortality for uveal melanoma in the Korean population and assess whether it correlates with cytogenetic data, and clinical and histopathological factors. METHODS: A retrospective review of medical files from 33 uveal melanoma patients who underwent enucleation at Yonsei University, Seoul, Korea, between January, 1994 and December, 2009 was performed. Dual-colour fluorescence in situ hybridization was performed using centromeric probes for chromosome 3 and 8 in archived patient tissues. RESULTS: The mean age of patients was 53.2 years (range; 29-78), and the mean largest basal diameter was 11.8 mm (range; 6.0-18.1). Of the 20 tissue blocks with available cytogenetic data, there was monosomy 3 in seven (35%) and polysomy 8 in four (20%). The presence of monosomy 3 (p < 0.001), polysomy 8 (p < 0.001), ciliary body involvement (p < 0.001), a mitotic rate ≥5/40 high-power fields (p = 0.006), closed extravascular matrix loop (p = 0.025), large basal tumour diameter (p = 0.029) and epithelioid cellularity (p = 0.038) predicted melanoma-related mortality. The median time from enucleation to liver metastasis was 16 months (range; 10-70), and the median survival after metastasis was 5 months (range; 1-9). The Kaplan--Meier survival curve estimated the metastatic death rate to be 22% for 5 years and 30% for 10 years. CONCLUSIONS: Korean patients with uveal melanoma are younger and appear to exhibit no worse prognosis than Caucasian. Cytogenetic abnormality of chromosome 3 and 8 highly predicted metastatic death. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | ACTA OPHTHALMOLOGICA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Chromosome Aberrations* | - |
dc.subject.MESH | Chromosomes, Human, Pair 3/genetics* | - |
dc.subject.MESH | Chromosomes, Human, Pair 8/genetics* | - |
dc.subject.MESH | Cytogenetic Analysis | - |
dc.subject.MESH | Eye Enucleation | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | In Situ Hybridization, Fluorescence | - |
dc.subject.MESH | Korea/epidemiology | - |
dc.subject.MESH | Liver Neoplasms/genetics* | - |
dc.subject.MESH | Liver Neoplasms/mortality | - |
dc.subject.MESH | Liver Neoplasms/secondary | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Melanoma/genetics* | - |
dc.subject.MESH | Melanoma/mortality | - |
dc.subject.MESH | Melanoma/secondary | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Survival Rate | - |
dc.subject.MESH | UvealNeoplasms/genetics* | - |
dc.subject.MESH | UvealNeoplasms/mortality | - |
dc.subject.MESH | UvealNeoplasms/pathology | - |
dc.title | Cytogenetics and prognosis for uveal melanoma in Korean patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Ophthalmology (안과학) | - |
dc.contributor.googleauthor | Christopher Seungkyu Lee | - |
dc.contributor.googleauthor | Junwon Lee | - |
dc.contributor.googleauthor | Jun Jeong Choi | - |
dc.contributor.googleauthor | Woo Ik Yang | - |
dc.contributor.googleauthor | Jin Sook Yoon | - |
dc.contributor.googleauthor | Sang Yeul Lee | - |
dc.contributor.googleauthor | Sung Chul Lee | - |
dc.identifier.doi | 10.1111/j.1755-3768.2010.02099.x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02300 | - |
dc.contributor.localId | A02611 | - |
dc.contributor.localId | A02819 | - |
dc.contributor.localId | A02873 | - |
dc.contributor.localId | A02913 | - |
dc.relation.journalcode | J00025 | - |
dc.identifier.eissn | 1755-3768 | - |
dc.identifier.pmid | 21310015 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/j.1755-3768.2010.02099.x/abstract | - |
dc.subject.keyword | cytogenetics | - |
dc.subject.keyword | Korea | - |
dc.subject.keyword | neoplasia | - |
dc.subject.keyword | uveal melanoma | - |
dc.contributor.alternativeName | Yang, Woo Ick | - |
dc.contributor.alternativeName | Yoon, Jin Sook | - |
dc.contributor.alternativeName | Lee, Sang Yeul | - |
dc.contributor.alternativeName | Lee, Sung Chul | - |
dc.contributor.alternativeName | Lee, Seung Kyu | - |
dc.contributor.affiliatedAuthor | Yang, Woo Ick | - |
dc.contributor.affiliatedAuthor | Yoon, Jin Sook | - |
dc.contributor.affiliatedAuthor | Lee, Sang Yeul | - |
dc.contributor.affiliatedAuthor | Lee, Sung Chul | - |
dc.contributor.affiliatedAuthor | Lee, Seung Kyu | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 89 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 310 | - |
dc.citation.endPage | 314 | - |
dc.identifier.bibliographicCitation | ACTA OPHTHALMOLOGICA, Vol.89(4) : 310-314, 2011 | - |
dc.identifier.rimsid | 27636 | - |
dc.type.rims | ART | - |
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