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Relationships among the lactulose breath test, intestinal gas volume, and gastrointestinal symptoms in patients with irritable bowel syndrome.

Authors
 Young Hoon Youn  ;  Jung Soo Park  ;  Jae Hoon Jahng  ;  Hyun Chul Lim  ;  Jie-Hyun Kim  ;  Mark Pimentel  ;  Hyojin Park  ;  Sang In Lee 
Citation
 DIGESTIVE DISEASES AND SCIENCES, Vol.56(7) : 2059-2066, 2011 
Journal Title
DIGESTIVE DISEASES AND SCIENCES
ISSN
 0163-2116 
Issue Date
2011
MeSH
Adult ; BreathTests* ; Constipation/physiopathology ; Diarrhea/physiopathology ; Female ; Flatulence/physiopathology* ; Humans ; Intestines/physiopathology ; IrritableBowelSyndrome/physiopathology* ; Lactulose* ; Male ; Middle Aged ; Prospective Studies ; Radiography, Abdominal ; Severity of Illness Index ; Surveys and Questionnaires
Keywords
IBS ; Intestinal gas volume ; Gas volume score (GVS) ; LBT
Abstract
BACKGROUND AND AIMS: Irritable bowel syndrome (IBS) patients frequently complain of gas-related symptoms, and the lactulose breath test (LBT) is a test that assesses the amount of fermented gas generated by bacteria in the bowel. We aimed to assess the relationship among intestinal gas volume, LBT result, and gastrointestinal symptom score in healthy control and functional bowel disorder (FBD) subjects.

METHOD: In 84 IBS subjects, 24 FBD subjects other than IBS, and 25 healthy controls, a symptom questionnaire that enquired about seven main symptoms, plain abdominal radiography and a LBT were checked on the same day. The intestinal gas volume was calculated as the gas volume score (GVS) with a digitalized image of plain supine abdominal radiographs.

RESULTS: The GVS was greater in the LBT (+) group compared to the LBT (-) group (P = 0.02). The GVS was greater in the FBD and IBS groups than in the control group (P < 0.01). The GVS showed low but positive correlations with the severity and frequency of bloating, flatulence, abdominal pain, constipation, and tenesmus (P < 0.05). The severity of flatulence (P = 0.02) and the frequency of bloating (P = 0.02) in the LBT (+) group were significantly higher than those in the LBT (-) group.

CONCLUSIONS: Subjects with positive LBT had more gas-related symptoms and greater gas volume scores. Gas-related symptoms, positive LBT and increased GVS were significantly associated to each other. These findings can broaden the understanding of the pathophysiologic mechanisms of gas-related symptoms in IBS.
Full Text
http://link.springer.com/article/10.1007%2Fs10620-011-1569-2
DOI
10.1007/s10620-011-1569-2
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jie-Hyun(김지현) ORCID logo https://orcid.org/0000-0002-9198-3326
Park, Hyo Jin(박효진) ORCID logo https://orcid.org/0000-0003-4814-8330
Youn, Young Hoon(윤영훈) ORCID logo https://orcid.org/0000-0002-0071-229X
Lee, Sang In(이상인)
Lim, Hyun Chul(임현철)
Jahng, Jae Hoon(장재훈)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93350
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