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Prestimulus top-down reflection of obsessive-compulsive disorder in EEG frontal theta and occipital alpha oscillations.

Authors
 Byoung-Kyong Min  ;  Se Joo Kim  ;  Jin Young Park  ;  Hae-Jeong Park 
Citation
 NEUROSCIENCE LETTERS, Vol.496(3) : 181-185, 2011 
Journal Title
NEUROSCIENCE LETTERS
ISSN
 0304-3940 
Issue Date
2011
MeSH
Adult ; Alpha Rhythm/physiology* ; Color Perception/physiology ; Diagnostic and Statistical Manual of Mental Disorders ; Discrimination (Psychology)/physiology ; Electroencephalography ; Female ; Form Perception/physiology ; Frontal Lobe/physiopathology* ; Humans ; Male ; Nerve Net/physiopathology ; Obsessive-Compulsive Disorder/physiopathology* ; Occipital Lobe/physiopathology* ; Psychiatric Status Rating Scales ; Psychomotor Performance/physiology ; Reaction Time/physiology ; Theta Rhythm/physiology* ; Young Adult
Keywords
Alpha activity ; Inhibition ; Obsessive-compulsive disorder ; Theta activity ; Top-down processing
Abstract
It has recently been reported that prestimulus electroencephalogram (EEG) frontal theta and occipital alpha oscillations of healthy controls were modulated by the type of upcoming tasks, reflecting prestimulus top-down preparation. The present study explored the differences in dynamics of frontal theta and occipital alpha activities between obsessive-compulsive disorder (OCD) patients and healthy participants in terms of reflection of prestimulus top-down regulation. EEGs were recorded from 16 OCD patients and 16 healthy controls using a color and a shape discrimination task. The power and time course of oscillatory activity were calculated by convolving the EEG signals with Morlet wavelets. Although OCD patients yielded significantly lower total alpha and total theta power results than the normal controls, they demonstrated that significantly higher total alpha and total theta power preceded the difficult task (shape-task) as compared to the easy task (color-task). Furthermore, the frontal region, where OCD patients usually revealed abnormalities, showed significant differences in the prestimulus total theta power between the normal and OCD groups. Taken together, frontal theta and occipital alpha oscillations seem to be potent electrophysiological correlates reflecting impairment in the prestimulus top-down processing of OCD patients.
Full Text
http://www.sciencedirect.com/science/article/pii/S0304394011004642
DOI
10.1016/j.neulet.2011.04.018
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Joo(김세주) ORCID logo https://orcid.org/0000-0002-5438-8210
Park, Jin Young(박진영) ORCID logo https://orcid.org/0000-0002-5351-9549
Park, Hae Jeong(박해정) ORCID logo https://orcid.org/0000-0002-4633-0756
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93343
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