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통풍의 병태 생리

Other Titles
 Pathophysiology of Gout 
Authors
 이광훈  ;  이수곤 
Citation
 Korean Journal of Medicine, Vol.80(3) : 251-254, 2011 
Journal Title
 Korean Journal of Medicine 
ISSN
 1226-329X 
Issue Date
2011
Abstract
We reviewed the pathophysiology of gout in this review article. Gout occurs as a response to monosodium urate crystal (MSU) that is present in joints, bones and soft tissue. Hyperuricemia in gout is mainly due to the decreased renal clearance of uric acid and is considered to be the cause of MSU formation. However, hyperuricemia alone does not explain the development of gout. Acute gout attack is due to the response to MSU, which is derived by innate immunity. Tophi are deposits of MSU and cell debris surrounded by granulomatous inflammation.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93340
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
이광훈(Lee, Kwang Hoon) ; 이수곤(Lee, Soo Kon)
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