Cited 22 times in
Crosstalk between platelet-derived growth factor-induced Nox4 activation and MUC8 gene overexpression in human airway epithelial cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김창훈 | - |
dc.contributor.author | 유지환 | - |
dc.contributor.author | 윤주헌 | - |
dc.contributor.author | 이상남 | - |
dc.contributor.author | 이정권 | - |
dc.contributor.author | 주정희 | - |
dc.date.accessioned | 2014-12-20T16:44:48Z | - |
dc.date.available | 2014-12-20T16:44:48Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0891-5849 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/93299 | - |
dc.description.abstract | Reactive oxygen species (ROS) contribute to chronic airway inflammation, and NADPH oxidase (Nox) is an important source of ROS. However, little is known of the role that ROS play in chronic upper respiratory tract inflammation. We investigated the mechanism of ROS generation and its association with mucin gene overexpression in the nasal epithelium. The level of platelet-derived growth factor (PDGF) expression was increased in sinusitis mucosa, and high-level PDGF expression induced intracellular ROS, followed by MUC8 gene overexpression in normal human nasal epithelial cells. Knockdown of Nox4 expression with Nox4 siRNA decreased PDGF-induced intracellular ROS and MUC8 expression. Infection with an adenovirus containing Nox4 cDNA resulted in Nox4 overexpression and increased intracellular levels of ROS and MUC8 expression. PDGF and Nox4 overexpression are essential components of intracellular ROS generation and may contribute to chronic inflammation in the nasal epithelium through induction of MUC8 overexpression. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1039~1052 | - |
dc.relation.isPartOf | FREE RADICAL BIOLOGY AND MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adenoviridae | - |
dc.subject.MESH | Blotting, Western | - |
dc.subject.MESH | Cell Culture Techniques | - |
dc.subject.MESH | Chronic Disease | - |
dc.subject.MESH | Enzyme Activation | - |
dc.subject.MESH | Epithelial Cells/enzymology | - |
dc.subject.MESH | Epithelial Cells/pathology | - |
dc.subject.MESH | Gene Expression Regulation | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Isoenzymes/genetics | - |
dc.subject.MESH | Isoenzymes/metabolism | - |
dc.subject.MESH | Mucins/genetics | - |
dc.subject.MESH | Mucins/metabolism* | - |
dc.subject.MESH | NADPH Oxidase 4 | - |
dc.subject.MESH | NADPH Oxidases/genetics | - |
dc.subject.MESH | NADPH Oxidases/metabolism* | - |
dc.subject.MESH | Nasal Mucosa/metabolism | - |
dc.subject.MESH | Nasal Mucosa/physiopathology | - |
dc.subject.MESH | Oxidative Stress | - |
dc.subject.MESH | Platelet-Derived Growth Factor/genetics | - |
dc.subject.MESH | Platelet-Derived Growth Factor/metabolism* | - |
dc.subject.MESH | RNA Interference | - |
dc.subject.MESH | RNA, Small Interfering/metabolism | - |
dc.subject.MESH | Reactive Oxygen Species/analysis | - |
dc.subject.MESH | Reactive Oxygen Species/metabolism | - |
dc.subject.MESH | Reverse Transcriptase Polymerase Chain Reaction | - |
dc.subject.MESH | Signal Transduction* | - |
dc.subject.MESH | Sinusitis/genetics | - |
dc.subject.MESH | Sinusitis/metabolism* | - |
dc.subject.MESH | Sinusitis/physiopathology | - |
dc.subject.MESH | Transduction, Genetic | - |
dc.subject.MESH | Tumor Cells, Cultured | - |
dc.title | Crosstalk between platelet-derived growth factor-induced Nox4 activation and MUC8 gene overexpression in human airway epithelial cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Otorhinolaryngology (이비인후과학) | - |
dc.contributor.googleauthor | Hyun Jik Kim | - |
dc.contributor.googleauthor | Chang-Hoon Kim | - |
dc.contributor.googleauthor | Ji-Hwan Ryu | - |
dc.contributor.googleauthor | Jung Hee Joo | - |
dc.contributor.googleauthor | Sang-Nam Lee | - |
dc.contributor.googleauthor | Min-Ji Kim | - |
dc.contributor.googleauthor | Jeung-Gweon Lee | - |
dc.contributor.googleauthor | Yun Soo Bae | - |
dc.contributor.googleauthor | Joo-Heon Yoon | - |
dc.identifier.doi | 10.1016/j.freeradbiomed.2011.01.014 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02604 | - |
dc.contributor.localId | A02813 | - |
dc.contributor.localId | A03095 | - |
dc.contributor.localId | A03958 | - |
dc.contributor.localId | A01050 | - |
dc.contributor.localId | A02522 | - |
dc.relation.journalcode | J00906 | - |
dc.identifier.eissn | 1873-4596 | - |
dc.identifier.pmid | 21255638 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0891584911000347 | - |
dc.subject.keyword | Platelet-derived growth factor | - |
dc.subject.keyword | MUC8 | - |
dc.subject.keyword | Nox4 | - |
dc.subject.keyword | Reactive oxygen species | - |
dc.subject.keyword | Free radicals | - |
dc.contributor.alternativeName | Kim, Chang Hoon | - |
dc.contributor.alternativeName | Ryu, Ji Hwan | - |
dc.contributor.alternativeName | Yoon, Joo Heon | - |
dc.contributor.alternativeName | Lee, Sang Nam | - |
dc.contributor.alternativeName | Lee, Jeung Gweon | - |
dc.contributor.alternativeName | Joo, Jung Hee | - |
dc.contributor.affiliatedAuthor | Yoon, Joo Heon | - |
dc.contributor.affiliatedAuthor | Lee, Sang Nam | - |
dc.contributor.affiliatedAuthor | Lee, Jeung Gweon | - |
dc.contributor.affiliatedAuthor | Joo, Jung Hee | - |
dc.contributor.affiliatedAuthor | Kim, Chang Hoon | - |
dc.contributor.affiliatedAuthor | Ryu, Ji Hwan | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 50 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1039 | - |
dc.citation.endPage | 1052 | - |
dc.identifier.bibliographicCitation | FREE RADICAL BIOLOGY AND MEDICINE, Vol.50(9) : 1039-1052, 2011 | - |
dc.identifier.rimsid | 27120 | - |
dc.type.rims | ART | - |
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