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Spontaneous remission of nephrotic syndrome in patients with IgA nephropathy.

Authors
 Seung Hyeok Han  ;  Ea Wha Kang  ;  Jeong Kyung Park  ;  Jeong Hae Kie  ;  Dae Suk Ha  ;  Shin-Wook Kang 
Citation
 NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol.26(5) : 1570-1575, 2011 
Journal Title
NEPHROLOGY DIALYSIS TRANSPLANTATION
ISSN
 0931-0509 
Issue Date
2011
MeSH
Adolescent ; Adult ; Aged ; Child ; Female ; Glomerulonephritis, IGA/complications* ; Glomerulonephritis, IGA/pathology ; Humans ; Kidney Failure, Chronic ; Kidney Function Tests ; Male ; Middle Aged ; Nephrotic Syndrome/etiology* ; Nephrotic Syndrome/pathology ; Proteinuria ; Remission, Spontaneous ; Treatment Outcome ; Young Adult
Keywords
IgA nephropathy ; nephrotic syndrome ; spontaneous remission
Abstract
BACKGROUND: IgA nephropathy (IgAN) can be complicated by nephrotic syndrome. Because the spontaneous resolution of heavy proteinuria is rare, corticosteroid therapy should be considered in such cases, particularly when IgAN is combined with minimal-change disease. Here, we report our experience of spontaneous remission of nephrotic syndrome in patients with IgAN and the long-term outcomes of these patients.

METHODS: Two hundred and thirty-three patients with biopsy-proven IgAN were enrolled between January 2001 and March 2009. Demographic, clinical and laboratory data were collected retrospectively based on medical records. In addition, pathologic findings were reviewed for glomerular and tubulointerstitial lesions. Outcome data for complete or partial remission, spontaneous remission, relapse, deterioration of renal function, and end-stage renal disease were recorded.

RESULTS: Twenty-four patients (10.3%) presented nephrotic syndrome. Among them, five patients underwent spontaneous remission within 6 months after the presentation of nephrotic syndrome. Interestingly, spontaneous remission occurred even in two patients who had elevated serum creatinine levels and advanced renal damage. During follow-up, neither recurrence nor relapse occurred, and no patients showed progressive deterioration of kidney function. Conclusions. This study suggests that spontaneous remission of nephrotic syndrome may occur in any stage of IgAN and carries a favourable long-term outcome without relapse. Given the possibility of under-reported cases, large-scale studies are required, and careful attention should be paid to such complicated cases.
Files in This Item:
T201101489.pdf Download
DOI
10.1093/ndt/gfq559
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Hospital Medicine (입원의학과) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Shin Wook(강신욱) ORCID logo https://orcid.org/0000-0002-5677-4756
Kang, Ea Wha(강이화)
Park, Jeong Kyung(박정경)
Han, Dae Suk(한대석)
Han, Seung Hyeok(한승혁) ORCID logo https://orcid.org/0000-0001-7923-5635
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93276
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