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The effect of 308nm excimer laser on segmental vitiligo: a retrospective study of 80 patients with segmental vitiligo.

Authors
 Jeong Eun Do  ;  Jae Yong Shin  ;  Do-Young Kim  ;  Seung-Kyung Hann  ;  Sang Ho Oh 
Citation
 PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE, Vol.27(3) : 147-151, 2011 
Journal Title
PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
ISSN
 0905-4383 
Issue Date
2011
MeSH
Adolescent ; Adult ; Child ; Child, Preschool ; Dose-Response Relationship, Radiation ; Female ; Humans ; Laser Therapy* ; Lasers ; Male ; Middle Aged ; Retrospective Studies ; Skin Pigmentation/radiation effects ; Ultraviolet Rays ; Ultraviolet Therapy* ; Vitiligo/pathology ; Vitiligo/therapy*
Keywords
excimer laser ; segmental type ; vitiligo.
Abstract
BACKGROUND: Segmental vitiligo (SV), which frequently accompanies poliosis, indicating a poor prognosis that is likely resistant to treatments.

OBJECTIVES: In this study, we performed a retrospective analysis to evaluate the treatment response to 308 nm excimer laser in SV patients.

METHODS: A retrospective chart and photographic review was performed on 80 SV patients who had been treated with 308nm excimer laser for >3 months. Results: Eighty patients with SV (mean age: 24.0 years ± 15.3, males: 50%) were included in this study. The mean grade of repigmentation was 2.3 after 20.6 months of mean treatment duration; 23.8% of 80 patients showed grade 4, 20% showed grade 3, and 56.2% showed grade 1-2 repigmentation. However, none of them achieved complete repigmentation with excimer laser. The degree of repigmentation was positively correlated with treatment duration (r=0.315, P=0.004) and cumulative ultraviolet (UV) dosage (r=0.366, P=0.001), whereas it was negatively correlated with disease duration (r=-0.265, P=0.017).

CONCLUSION: This study suggests that SV has a better repigmentation response when excimer laser is used at earlier stages of the disease and long-term use and high cumulative UV energy of the excimer laser elicit better responses. Additional treatments like surgical procedures in addition to excimer laser should be considered for complete repigmentation
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0781.2011.00587.x/abstract
DOI
10.1111/j.1600-0781.2011.00587.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Do Young(김도영) ORCID logo https://orcid.org/0000-0002-0194-9854
Do, Jeong Eun(도정은)
Shin, Jae Yong(신재용) ORCID logo https://orcid.org/0000-0002-2955-6382
Oh, Sang Ho(오상호) ORCID logo https://orcid.org/0000-0002-4477-1400
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93190
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