Cited 8 times in
Nomogram to predict insignificant prostate cancer at radical prostatectomy in Korean men: a multi-center study
DC Field | Value | Language |
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dc.contributor.author | 송혜령 | - |
dc.contributor.author | 유호송 | - |
dc.contributor.author | 정재승 | - |
dc.contributor.author | 최영득 | - |
dc.date.accessioned | 2014-12-20T16:39:48Z | - |
dc.date.available | 2014-12-20T16:39:48Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/93140 | - |
dc.description.abstract | PURPOSE: Due to the availability of serum prostate specific antigen (PSA) testing, the detection rate of insignificant prostate cancer (IPC) is increasing. To ensure better treatment decisions, we developed a nomogram to predict the probability of IPC. MATERIALS AND METHODS: The study population consisted of 1,471 patients who were treated at multiple institutions by radical prostatectomy without neoadjuvant therapy from 1995 to 2008. We obtained nonrandom samples of n = 1,031 for nomogram development, leaving n = 440 for nomogram validation. IPC was defined as pathologic organ-confined disease and a tumor volume of 0.5 cc or less without Gleason grade 4 or 5. Multivariate logistic regression model (MLRM) coefficients were used to construct a nomogram to predict IPC from five variables, including serum prostate specific antigen, clinical stage, biopsy Gleason score, positive cores ratio and maximum % of tumor in any core. The performance characteristics were internally validated from 200 bootstrap resamples to reduce overfit bias. External validation was also performed in another cohort. RESULTS: Overall, 67 (6.5%) patients had a so-called "insignificant" tumor in nomogram development cohort. PSA, clinical stage, biopsy Gleason score, positive core ratio and maximum % of biopsy tumor represented significant predictors of the presence of IPC. The resulting nomogram had excellent discrimination accuracy, with a bootstrapped concordance index of 0.827. CONCLUSION: Our current nomogram provides sufficiently accurate information in clinical practice that may be useful to patients and clinicians when various treatment options for screen-detected prostate cancer are considered | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 74~80 | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Asian Continental Ancestry Group | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Logistic Models | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Nomograms* | - |
dc.subject.MESH | Prostatectomy | - |
dc.subject.MESH | Prostatic Neoplasms/diagnosis* | - |
dc.subject.MESH | Prostatic Neoplasms/surgery | - |
dc.title | Nomogram to predict insignificant prostate cancer at radical prostatectomy in Korean men: a multi-center study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Medical Research Center (임상의학연구센터) | - |
dc.contributor.googleauthor | Jae Seung Chung | - |
dc.contributor.googleauthor | Han Yong Choi | - |
dc.contributor.googleauthor | Hae-Ryoung Song | - |
dc.contributor.googleauthor | Seok-Soo Byun | - |
dc.contributor.googleauthor | Seong Il Seo | - |
dc.contributor.googleauthor | Cheryn Song | - |
dc.contributor.googleauthor | Jin Seon Cho | - |
dc.contributor.googleauthor | Sang Eun Lee | - |
dc.contributor.googleauthor | Hanjong Ahn | - |
dc.contributor.googleauthor | Eun Sik Lee | - |
dc.contributor.googleauthor | Tae-Kon Hwang | - |
dc.contributor.googleauthor | Wun-Jae Kim | - |
dc.contributor.googleauthor | Moon Kee Chung | - |
dc.contributor.googleauthor | Tae Young Jung | - |
dc.contributor.googleauthor | Ho Song Yu | - |
dc.contributor.googleauthor | Young Deuk Choi | - |
dc.identifier.doi | 10.3349/ymj.2011.52.1.74 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02079 | - |
dc.contributor.localId | A02534 | - |
dc.contributor.localId | A03707 | - |
dc.contributor.localId | A04111 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 21155038 | - |
dc.subject.keyword | Prostatic neoplasms | - |
dc.subject.keyword | nomograms | - |
dc.subject.keyword | insignificant | - |
dc.contributor.alternativeName | Song, Hae Ryoung | - |
dc.contributor.alternativeName | Yu, Ho Song | - |
dc.contributor.alternativeName | Chung, Jae Seung | - |
dc.contributor.alternativeName | Choi, Young Deuk | - |
dc.contributor.affiliatedAuthor | Song, Hae Ryoung | - |
dc.contributor.affiliatedAuthor | Yu, Ho Song | - |
dc.contributor.affiliatedAuthor | Chung, Jae Seung | - |
dc.contributor.affiliatedAuthor | Choi, Young Deuk | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 52 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 74 | - |
dc.citation.endPage | 80 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.52(1) : 74-80, 2011 | - |
dc.identifier.rimsid | 28057 | - |
dc.type.rims | ART | - |
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