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Mucous membrane pemphigoid with immunoglobulin G autoantibodies against full-length and 120-kDa ectodomain of BP180

Authors
 Yuri CHOI  ;  Sang Eun LEE  ;  Shunpei FUKUDA  ;  Takashi HASHIMOTO  ;  Soo-Chan KIM 
Citation
 JOURNAL OF DERMATOLOGY, Vol.38(2) : 169-172, 2011 
Journal Title
JOURNAL OF DERMATOLOGY
ISSN
 0385-2407 
Issue Date
2011
MeSH
Aged ; Autoantibodies/blood* ; Autoantigens/immunology* ; Humans ; Immunoglobulin G/blood ; Immunoglobulin G/immunology* ; Male ; Non-Fibrillar Collagens/immunology* ; Pemphigoid, Benign Mucous Membrane/immunology* ; Pemphigoid, Bullous/immunology*
Keywords
bullous pemphigoid antigen 2 ; LAD-1 ; mucous membrane pemphigoid.
Abstract
Mucous membrane pemphigoid (MMP) is a rare autoimmune, subepidermal, bullous disease characterized by erosive lesions on the mucous membranes and skin. MMP reacts with various target antigens including BP180, laminin-332, β4 integrin, α6 integrin or type VII collagen. We present a 67-year-old male MMP patient who had lesions on the oral and ocular mucous membranes and facial skin. By immunoblot analyses, immunoglobulin G autoantibodies in the patient's sera reacted with full-length BP180 and the 120-kDa ectodomain of BP180 (LAD-1).
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1346-8138.2010.01072.x/abstract
DOI
10.1111/j.1346-8138.2010.01072.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Soo Chan(김수찬) ORCID logo https://orcid.org/0000-0002-2327-4755
Lee, Sang Eun(이상은) ORCID logo https://orcid.org/0000-0003-4720-9955
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93116
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