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Association between expression of embryonic lethal abnormal vision-like protein HuR and cyclooxygenase-2 in oral squamous cell carcinoma.

Authors
 Jeong-Dan Cha  ;  ShengJin Li  ;  In-Ho Cha 
Citation
 Head & Neck, Vol.33(5) : 627-637, 2011 
Journal Title
 Head & Neck 
ISSN
 1043-3074 
Issue Date
2011
Abstract
BACKGROUND: Increased cytoplasmic HuR expression has been noted in several cancer types, where it may contribute to the increased cyclooxygenase-2 (COX-2) expression observed during tumorigenesis and metastasis. METHODS: To assess the correlation between COX-2 and HuR in oral squamous cell carcinoma (OSCC), the expression patterns of HuR and COX-2 were assessed via immunohistochemistry analyses of 103 OSCC samples. RESULTS: Cytoplasmic HuR expression was significantly associated with COX-2 expression (p < .025) and lymph node metastasis (p < .050) and distant metastasis (p < .025). In multivariate analysis, cytoplasmic HuR expression was identified as an independent prognostic parameter for reduced overall survival. The inhibition of HuR expression by siRNA or leptomycin B (LMB) caused a reduction in the inducibility of COX-2 in oral cancer cells. CONCLUSION: Our results indicate that the cytoplasmic expression of HuR is associated with COX-2 expression in OSCCs and HuR can regulate COX-2 expression in oral cancer cell lines.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93067
DOI
10.1002/hed.21507
Appears in Collections:
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실)
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Oral Cancer Research Institute (구강종양연구소)
Yonsei Authors
차인호(Cha, In Ho) ; 차정단(Cha, Jeong Dan)
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Full Text
http://onlinelibrary.wiley.com/doi/10.1002/hed.21507/abstract;jsessionid=69647A1433E946DB0134525A353EB4E3.f02t01
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