Cited 19 times in
Bone formation of Escherichia coli expressed rhBMP-2 on absorbable collagen block in rat calvarial defects
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 엄유정 | - |
dc.contributor.author | 윤정호 | - |
dc.contributor.author | 정의원 | - |
dc.contributor.author | 조규성 | - |
dc.contributor.author | 최성호 | - |
dc.contributor.author | 김창성 | - |
dc.date.accessioned | 2014-12-20T16:32:54Z | - |
dc.date.available | 2014-12-20T16:32:54Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1079-2104 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/92926 | - |
dc.description.abstract | OBJECTIVES: The aim of this study was to evaluate the osteogenic and space-providing effect of rhBMP-2 produced in an Escherichia coli expression system (ErhBMP-2) with absorbable collagen block (ACB) as the carrier system in the rat calvarial defect model. STUDY DESIGN: Eight-millimeter diameter calvarial defects were created in 60 male Sprague-Dawley rats. The animals were divided into 6 groups containing 10 animals each that received sham-surgery control (no material applied), ACB control (ACB alone), or ErhBMP-2/ACB (ACB loaded with 0.025 mg/mL ErhBMP-2). Histological and histometric analysis was performed after 2- and 8-week healing intervals. RESULTS: On histological observation, the level of bone formation in the defects was generally higher at 8 weeks than at 2 weeks. Surgical implantation of ErhBMP-2/ACB resulted in the enhanced bone regeneration compared with controls. Moreover, the collagen remnants of ACB appeared to be completely resorbed in ACB control and ErhBMP-2/ACB group after 8 weeks. Histometic analysis revealed that the ErhBMP-2/ACB group had a significantly greater augmented area, new bone area, and new bone ratio after 2 and 8 weeks than both control groups. However, there was no difference between 2 and 8 weeks in the ErhBMP-2/ACB group in all aspects of the augmented area, new bone area, and new bone ratio (P < .05). CONCLUSION: ErhBMP-2 loaded on ACB can induce favorable bone formation in the rat calvarial defect model, but this collagen carrier in block type did not fulfill the space-maintaining expectations for bone formation by ErhBMP-2. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 298~305 | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Absorbable Implants* | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Biocompatible Materials/therapeutic use* | - |
dc.subject.MESH | Bone Marrow/pathology | - |
dc.subject.MESH | Bone Matrix/pathology | - |
dc.subject.MESH | Bone Morphogenetic Protein 2 | - |
dc.subject.MESH | Bone Morphogenetic Proteins/therapeutic use | - |
dc.subject.MESH | Bone Regeneration/physiology | - |
dc.subject.MESH | Calcification, Physiologic/physiology | - |
dc.subject.MESH | Collagen/therapeutic use* | - |
dc.subject.MESH | Connective Tissue/pathology | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Drug Carriers | - |
dc.subject.MESH | Escherichia coli* | - |
dc.subject.MESH | Image Processing, Computer-Assisted/methods | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Osteoblasts/pathology | - |
dc.subject.MESH | Osteocytes/pathology | - |
dc.subject.MESH | Osteogenesis/physiology* | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Recombinant Proteins/therapeutic use | - |
dc.subject.MESH | Skull/pathology | - |
dc.subject.MESH | Skull/surgery* | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Transforming Growth Factor beta/therapeutic use | - |
dc.title | Bone formation of Escherichia coli expressed rhBMP-2 on absorbable collagen block in rat calvarial defects | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Periodontology (치주과학) | - |
dc.contributor.googleauthor | Jee-Hee Jung | - |
dc.contributor.googleauthor | Jeong-Ho Yun | - |
dc.contributor.googleauthor | Yoo-Jung Um | - |
dc.contributor.googleauthor | Ui-Won Jung | - |
dc.contributor.googleauthor | Chang-Sung Kim | - |
dc.contributor.googleauthor | Seong-Ho Choi | - |
dc.contributor.googleauthor | Kyoo-Sung Cho | - |
dc.identifier.doi | 10.1016/j.tripleo.2010.05.011 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02336 | - |
dc.contributor.localId | A02596 | - |
dc.contributor.localId | A03692 | - |
dc.contributor.localId | A03810 | - |
dc.contributor.localId | A01041 | - |
dc.contributor.localId | A04081 | - |
dc.relation.journalcode | J02443 | - |
dc.identifier.eissn | 1528-395X | - |
dc.identifier.pmid | 20875759 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S1079210410003239 | - |
dc.contributor.alternativeName | Um, Yoo Jung | - |
dc.contributor.alternativeName | Yun, Jeong Ho | - |
dc.contributor.alternativeName | Jung, Ui Won | - |
dc.contributor.alternativeName | Cho, Kyoo Sung | - |
dc.contributor.alternativeName | Choi, Seong Ho | - |
dc.contributor.alternativeName | Kim, Chang Sung | - |
dc.contributor.affiliatedAuthor | Um, Yoo Jung | - |
dc.contributor.affiliatedAuthor | Yun, Jeong Ho | - |
dc.contributor.affiliatedAuthor | Jung, Ui Won | - |
dc.contributor.affiliatedAuthor | Cho, Kyoo Sung | - |
dc.contributor.affiliatedAuthor | Kim, Chang Sung | - |
dc.contributor.affiliatedAuthor | Choi, Seong Ho | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 111 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 298 | - |
dc.citation.endPage | 305 | - |
dc.identifier.bibliographicCitation | ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS, Vol.111(3) : 298-305, 2011 | - |
dc.identifier.rimsid | 27907 | - |
dc.type.rims | ART | - |
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