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Cyclosporin A therapy for Henoch-Schönlein nephritis with nephrotic-range proteinuria

Authors
 Jee Min Park  ;  Sung Chul Won  ;  Jae Il Shin  ;  Hyunee Yim  ;  Ki Soo Pai 
Citation
 PEDIATRIC NEPHROLOGY, Vol.26(3) : 411-417, 2011 
Journal Title
PEDIATRIC NEPHROLOGY
ISSN
 0931-041X 
Issue Date
2011
MeSH
Adolescent ; Biopsy ; Child ; Child, Preschool ; Cyclosporine/adverse effects ; Cyclosporine/therapeutic use* ; Female ; Humans ; Immunosuppressive Agents/adverse effects ; Immunosuppressive Agents/therapeutic use* ; Male ; Nephritis/diagnosis ; Nephritis/drug therapy* ; Nephritis/etiology ; Nephrotic Syndrome/diagnosis ; Nephrotic Syndrome/drug therapy* ; Nephrotic Syndrome/etiology ; Proteinuria/diagnosis ; Proteinuria/drug therapy* ; Proteinuria/etiology ; Purpura, Schoenlein-Henoch/complications ; Purpura, Schoenlein-Henoch/diagnosis ; Purpura, Schoenlein-Henoch/drug therapy* ; Republic of Korea ; Retrospective Studies ; Time Factors ; Treatment Outcome
Keywords
Henoch–Schönlein nephritis ; Cyclosporin A ; Nephrotic-range proteinuria
Abstract
To evaluate the therapeutic role of cyclosporin A (CyA) for the treatment of Henoch-Schönlein nephritis (HSN), 29 patients (18 boys, 11 girls) with nephrotic-range proteinuria were analyzed retrospectively. Mean age was 8.6 years (range 2.0-15.5 years) at diagnosis of Henoch-Schönlein purpura (HSP). All patients had developed the nephrotic-range proteinuria at a mean interval of 4.4 months (range 0-50.7 months) after the diagnosis of HSP. Mean duration of CyA treatment was 12.3 months (range 2.6-55.0 months). Mean follow-up times were 3.7 years (range 1.2-12.9 years) from the beginning of the CyA treatment. Steroids were tapered off and stopped gradually after initiation of CyA. All patients responded to the CyA treatment within a mean of 1.8 months (range 1 week to 3.5 months). Twenty-three patients achieved stable remission with mean follow-up duration of 3.2 years and 6 patients seemed to become CyA-dependent, since they developed proteinuria when the treatment was stopped. Renal function was preserved in all patients but one who developed end-stage renal disease after poor compliance with CyA. We concluded that CyA treatment for HSN showing nephrotic-range proteinuria is very effective and a safe method, although some patients become CyA-dependent.
Full Text
http://dx.doi.org/10.1007/s00467-010-1723-7
DOI
10.1007/s00467-010-1723-7
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Shin, Jae Il(신재일) ORCID logo https://orcid.org/0000-0003-2326-1820
Won, Sung Chul(원성철)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/92903
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