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소아 천식에서 측정기기에 따른 호기산화질소 농도의 비교

Other Titles
 Comparison of Exhaled Nitric Oxide Analyzers in Childhood Asthma 
 이지현  ;  최봉석  ;  백지영  ;  이용주  ;  김경원  ;  손명현  ;  김규언 
 Pediatric Allergy and Respiratory Disease (소아알레르기 호흡기학회지), Vol.21(1) : 17-23, 2011 
Journal Title
Pediatric Allergy and Respiratory Disease(소아알레르기 호흡기학회지)
Issue Date
Asthma ; Bronchodilator response ; Atopy ; Non-atopy ; Child

The measurement of exhaled nitric oxide (eNO) is a noticeable tool that reflects asthmatic airway inflammation. However, the eNO values might be variable according to the patient's condition and the method of measurement. The aim of this study was to compare the values of eNO measured by two different eNO analyzers in asthmatic children (Niox mino® [Aerocrine; Solna, Sweden] and CLD88® [Eco Medics; Durten, Switzerland].


One hundred four asthmatic children and 59 healthy controls were enrolled. The study participants underwent pulmonary function testing before and after inhaled bronchodilator treatment, a methacholine provocation test, and sputum induction; the eNO concentration was then measured.


The value of eNO measured by Niox mino® was significantly lower than the value of eNO measured by CLD88® (30.7±25.0 vs. 38.6±29.2 ppb, P<0.001). The intraclass correlation coefficient was 0.786 (P<0.001). The eNO concentration was significantly increased in asthmatic children than controls (38.4±27.9 vs. 17.2±9.0 ppb, P <0.001 by Niox mino®; 47.8±31.8 vs. 22.2±12.7 ppb, P<0.001 by CLD88®). The eNO concentration was significantly correlated with the FEV1/FVC (r=-0.382, P<0.001 [Niox mino®]; r=-0.273, P=0.001 [CLD88®], percent sputum eosinophils (r=0.257, P=0.032 [Niox mino®]; r=0.297, P=0.017 [CLD88®]), and PC20 (r=-0.333, P<0.001 [by Niox mino®] r=-0.240, P=0.003 [CLD88®]).


The measurement of eNO might be a supportive tool for the diagnosis of asthma in children; however, the eNO values differ according to analyzers.
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1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Won(김경원) ORCID logo https://orcid.org/0000-0003-4529-6135
Kim, Kyu Earn(김규언)
Baek, Ji Young(백지영)
Sohn, Myung Hyun(손명현) ORCID logo https://orcid.org/0000-0002-2478-487X
Lee, Yong Ju(이용주) ORCID logo https://orcid.org/0000-0002-0796-2558
Choi, Bong Seok(최봉석)
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